ACRO | 在臨床試驗中用於CD19 CAR檢測檢出PE標記的抗FMC63抗體

ACRO | 在臨床試驗中用於CD19 CAR檢測檢出PE標記的抗FMC63抗體

2020.12.04

You don’t want to miss this!

 

Check Out PE-Labeled Anti-FMC63 Antibody for CD19 CAR Detection in Clinical Trials

FMC63 is an IgG2a mouse monoclonal antibody targeting CD19. So far, most of reported CART19 trials contain the anti-CD19 scFv derived from FMC63, including the three FDA-approved CARs Kymriah, Yescarta and Tecartus. Anti-FMC63 scFv antibody can specifically recognize the antigen-recognition domain of FMC63 derived anti-CD19 CARs and has been used for detecting anti-CD19 CAR expression, but it is difficult to find the commercial anti-FMC63 antibodies with high quality.

ACROBiosystems has developed the PE-labeled anti-FMC63 antibody (Cat. No. FM3-HPY53) with high sensitivity and high specificity as verified by FACS. This antibody can deal with the challenge such as the complex component of samples, low level of CAR positive cells and high background during the detection of anti-CD19 CAR-T cells in clinical trials. Besides PE-labeled anti-FMC63 antibody, FITC-labeled anti-FMC63 antibody and biotinylated anti-FMC63 antibody are also available to help expedite your anti-CD19 CAR T-cell therapy development.

FACS Data

Product: PE-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45)

Cat. No: FM3-HPY53

1e6 of the Anti-CD19 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45) (Cat. No. FM3-HPY53) and negative control antibody respectively, PE signal was used to evaluate the binding activity (QC tested).

Product: FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45)

Cat. No: FM3-FY45

2e5 of Anti-CD19 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) FITC-Labeled Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Cat. No. FM3-FY45) and isotype control respectively. FITC signal was used to evaluate the binding activity (QC tested).

Product: Biotinylated Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Y45)

Cat. No: FM3-BY45

2e5 of Anti-CD19 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) Biotinylated Monoclonal Anti-FMC63 scFv Antibody, Mouse IgG1 (Cat. No. FM3-BY45) and isotype control respectively, washed and then followed by PE-SA and analyzed with FACS (QC tested).

Product List

>> If you have any customized request for anti-FMC63 scFv antibody, please click here.

>> Click here to learn more about targets of CAR-T cell therapy

>> Click here to learn more about high affinity CD19 protein

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