ACRO_ELISA Assay Kits for Quantitative Analysis of Therapeutic Antibodies in Serum Samples

ACRO_ELISA Assay Kits for Quantitative Analysis of Therapeutic Antibodies in Serum Samples

2018.05.15

 Quantitative Analysis of mAb in Serum

 

Introduction

Pharmacokinetics (PK) is a branch of science dedicated to the quantitative analysis of absorption, distribution, metabolism and excretion of drug molecules within the body of a living organism. All pre-clinical and clinical studies include the measurement of serum drug concentration, both in animals and in patients, at different points after drug administration. The result is an important indicator of the drug’s pharmacokinetic properties, and is pertinently relevant to dosing recommendations.

The booming market of biologic drugs, driven by a flurry of success with monoclonal antibodies, brings the need for standard high throughput assays to evaluate the content of mAbs in serum samples. Traditionally, the analyses are conducted by indirect ELISA, or with the help of anti-drug antibodies (ADA), each with its own pros and cons. We have developed a series of assays based on the competitive ELISA method. The assay employs a biotinylated mAb against the same target as a tracer to compete with the unlabeled analyte, and uses the interaction between biotin and streptavidin for the eventual readout. This method does not rely on ADAs, and it also alleviates the background issue often occurred with the traditional assay format.

We have launched kits for the studies of CTLA-4, PD-1, and HER-2, respectively, in both humans, and common experimental animals.

Application for Free Sample
  • Promotion Period: 2018. Apr. 01 – 2018. May. 31;

  • Eligibility: One kit per customer (96 tests);

  • Application Method: Click the links below for corresponding products and fill in the trial application form;

  • Interested in one or more of the products below? Please feel free to send enquires to PK@acrobiosystems.com.

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