Alomone_Ion Channels | New & Featured Products

Alomone_Ion Channels | New & Featured Products

2018.09.17

 

New & Featured Products – Sep 14, 2018

 

Each month Alomone Labs releases a number of new antibodies, toxins and small molecules. For a complete list, visit our New Products page.

Antibodies

Rabbit polyclonals

Anti-CNIH2/3 (extracellular) Antibody (#AGC-047)

Anti-ASIC5 (extracellular) Antibody (#ASC-032)

Anti-KCa3.1 (SK4, IKCa1) Antibody (#APC-064)

Anti-TRPM4 Antibody (#ACC-044)

Anti-Ryanodine Receptor 2 Antibody (#ARR-002)

Anti-Kir6.2 Antibody (#APC-020)

Anti-GABA(A) α1 Receptor (extracellular) Antibody (#AGA-001)

Anti-HCN1 Antibody (#APC-056)

Anti-Aquaporin 2 Antibody (#AQP-002)

Anti-NaV1.8 Antibody (#ASC-016)

Anti-NMDAR2A (GluN2A) (extracellular) Antibody (#AGC-002)

Anti-CFTR Antibody (#ACL-006)

Anti-KV1.3 Antibody (#APC-002)

Anti-sloβ1 (KCNMB1) Antibody (#APC-036)

Anti-ASIC3 Antibody (#ASC-018)

Anti-CaV2.3 Antibody (#ACC-006)

Anti-HCN1 Antibody (#APC-056)


Immunohistochemical staining mouse cerebellum:

APC-056

Anti-HCN1 Antibody (#APC-056). HCN1 (green) appears in the cerebellar pinceau.

Anti-GABA(A) α1 Receptor (extracellular) Antibody (#AGA-001)

Immunocytochemical staining of intact living rat pheochromocytoma PC12 cells:

AGA-001

Extracellular staining of cells using Anti-GABA(A) α1 Receptor (extracellular) Antibody (#AGA-001), (1:100), (red).

Conjugated rabbit polyclonals

Anti-5HT3B Receptor (extracellular)-ATTO-488 Antibody (#ASR-032-AG)

Anti-GluR1 (AMPA Receptor 1) (extracellular)-ATTO-594 Antibody (#AGC-004-AR)

Anti-Aquaporin 4 (300-314)-ATTO-594 Antibody (#AQP-014-AR)

Anti-CaV1.2 (CACNA1C)-ATTO-488 Antibody (#ACC-003-AG)

Anti-KV1.3 (extracellular)-FITC Antibody (#APC-101-F)

Anti-KV11.1 (HERG) (extracellular)-FITC Antibody (#APC-109-F)

Anti-Nicotinic Acetylcholine Receptor α7 (extracellular)-FITC Antibody (#ANC-007-F)

Anti-Human Orai1 (extracellular)-FITC Antibody (#ACC-060-F)

Anti-P2X7 Receptor (extracellular)-FITC Antibody (#APR-008-F)

Anti-GluR1 (AMPA Receptor 1) (extracellular)-ATTO-594 Antibody (#AGC-004-AR)

Immunocytochemical staining of human live intact glioblastoma U-87 MG cells:

AGC-004-AR

Extracellular staining of cells with Anti-GluR1 (AMPA Receptor 1) (extracellular)-ATTO-594 Antibody (#AGC-004-AR), (1:25), (red).

Anti-Nicotinic Acetylcholine Receptor α7 (ext.)-FITC Antibody (#ANC-007-F)

Direct flow cytometry of live intact mouse J774 macrophage cells:

ANC-007-F

___ Cells.
___ Cells + rabbit IgG isotype control-FITC.
___ Cells + Anti-Nicotinic Acetylcholine Receptor α7 (extracellular)-FITC Antibody (#ANC-007-F), (5 µg).

Guinea pig polyclonals

Guinea pig Anti-TRPC6 Antibody (#AGP-002)

Guinea pig Anti-KCa2.2 (SK2) Antibody (#AGP-045)

Guinea pig Anti-GluR2 (GluA2) (extracellular) Antibody (#AGP-073)

Guinea pig Anti-CaVγ2 Antibody (#AGP-069)

Guinea pig Anti-TRPV1 (VR1) Antibody (#AGP-118)

Guinea pig Anti-TRPV1 (VR1) Antibody
(#AGP-118)


Immunohistochemical staining of TRPV1 in rat dorsal root ganglion (DRG):

AGP-118

Guinea pig Anti-TRPV1 (VR1) Antibody (#AGP-118), (1:200). TRPV1 staining (red) appears in some DRG cells.

Guinea pig Anti-KCa2.2 (SK2) Antibody (#AGP-045)

Western blot analysis of rat brain lysate and mouse brain lysate:

AGP-045

1, 2. Guinea pig Anti-KCa2.2 Antibody (#AGP-045), (1:1000).
3, 4. Guinea pig Anti-KCa2.2 Antibody, preincubated with the control peptide antigen.

Ion Channel Modulators

PF-05241328 (#P-345): NaV1.7 channel blocker

NaV1.7-Compound 36 (#CMN-003): NaV1.7 channel blocker

Ro 25-6981 maleate (#R-180): GluN2B-containing NMDA receptor antagonist

ATX-II (#STA-700): NaV channel activator

α-Bungarotoxin (#B-100): α7 nAChR antagonist

α-Dendrotoxin (#D-350): KV1.1, KV1.2, KV1.6 channel blocker

Guangxitoxin-1E (#STG-200): KV2 channel blocker

CNQX disodium salt (#C-141): AMPA/Kainate receptor antagonist

A-889425 (#A-195): TRPV1 channel blocker

CyPPA (#C-110): KCa2.2 and KCa2.3 channel activator

Hainantoxin-III (#STH-120): TTX-Sensitive NaV channel blocker

Jingzhaotoxin-II (#STJ-150): NaV channel activator

C-110

CyPPA

Ro 25-6981 maleate (#R-180)

GluN2B-containing NMDA receptor antagonist

R-180

Alomone Labs Ro 25-6981 maleate inhibits NMDA receptor channels:

R-180

A. Representative time course of NR1/NR2A currents, elicited by transient stimulations with 100 µM glutamate + 100 µM glycine every 50 sec, while membrane potential was held at -80 mV. 3 min application (indicated by bar) of 100 µM Ro 25-6981 maleate (#R-180) significantly inhibits current amplitude. B. Superimposed current traces from the recording shown in A, upon application of control and of 100 µM Ro 25-6981 maleate (as indicated).

NaV1.7-Compound 36 (#CMN-003)

NaV1.7 channel blocker

CMN-003

Alomone Labs NaV1.7-Compound 36 blocks NaV1.7 channels:

CMN-003

A. Representative time course of NaV1.7-Compound 36 (#CMN-003) inhibition of NaV1.7 channel peak currents. Membrane potential was held at -100 mV. Current was elicited by a 100 ms voltage step to 0 mV every 10 sec and inhibited by 10 µM and 50 µM NaV1.7-Compound 36 application (horizontal bars). B. Superimposed traces of NaV1.7 current upon application of control and of 10 µM and 50 µM NaV1.7-Compound 36, as indicated.

α-Conotoxin GI (#STC-500): α1/β1/δ/γ nAChR antagonist

Gabazine hydrobromide (#G-216): GABA(A) receptor antagonist

Picrotoxin (#P-325): GABA(A) receptor antagonist

MmTX1 (#STM-550): GABA(A) receptor allosteric modulator

Urotoxin (#STU-200): KV1.2 channel blocker

BzATP triethylammonium salt (#A-385): P2X7 receptor agonist

Hm1a (#STH-601): NaV1.1 channel activator

BmKI (#STB-100): NaV channel activator

CAY10593 (VU0155069) (#C-385): P2X7 receptor antagonist

JNJ-47965567 (#J-115): P2X7 receptor antagonist

P-325

Picrotoxin

MmTX1 (#STM-550)

GABA(A) receptor allosteric modulator

STM-550

Alomone Labs MmTX1 modulates GABA(A) receptors:

STM-550

A. Representative time course of GABA(A) α1/β2 current activated at a holding potential of -80 mV by 100 nM Muscimol hydrobromide (#M-240) applications (black bars), and modulated by co-application of 200 nM MmTX1 (#STM-550), as indicated (green bar). A significant modulation of receptor desensitization and reactivation rates is observed. B. Superimposed traces of GABA(A) receptor currents upon application of 100 nM Muscimol (black) or co-application of 100 nM Muscimol and 200 nM MmTX1 (green). Taken from the recording in A.

JNJ-47965567 (#J-115)

P2X7 receptor antagonist

J-115

Alomone Labs JNJ-47965567 inhibits human P2X7 receptors:

J-115

Dose response curve of hP2X7 inhibition by JNJ-47965567 (#J-115). Cells were loaded with Fluo-8 NW dye, incubated with increasing concentrations of JNJ-47965567, and stimulated with 80 µM BzATP. Changes in intracellular Ca2+ following agonist application were detected as changes in maximum relative fluorescence (RLU) using FLIPRTETRA™. IC50 was calculated at 69 nM.

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