Alomone_P2X7 Receptor | Novel & Selective P2X7 Receptor Antagonists!

Alomone_P2X7 Receptor | Novel & Selective P2X7 Receptor Antagonists!

2018.09.17

Sep 17, 2018

P2X7 Receptor

The activity of all products undergoes strict testing in relevant biological systems. New lots are compared to previous ones.

 

AZ11645373 (#A-395)
Effective concentration: 0.1-5 µM

A-804598 (#A-415)
Effective concentration: 1-100 nM

AACBA hydrochloride (#A-410)
Effective concentration: 1-100 nM

AZ 10606120 dihydrochloride (#A-405)
Effective concentration: 1-100 nM

A-740003 (#A-420)
Effective concentration: 10 nM – 1 µM

AZD-9056 hydrochloride (#A-425)
Effective concentration: 1-100 nM

A-839977 (#A-470)
Effective concentration: 1-50 nM

JNJ-54166060 (#J-125)
Effective concentration: 10 nM – 1 µM

ZINC58368839 (#Z-135)
Effective concentration: 5-500 µM

ZINC9315614 (#Z-145)
Effective concentration: 0.1-10 µM

A-415

A-804598

 

A-410

AACBA hydrochloride

 

A-420

A-740003

AZ 10606120 dihydrochloride (#A-405)

A-405

Alomone Labs AZ 10606120 dihydrochloride inhibits human P2X7 receptors:

A-405

Dose response curve of hP2X7 inhibition by AZ 10606120 dihydrochloride (#A-405). Cells were loaded with Fluo-8 NW dye, incubated with increasing concentrations of AZ 10606120 dihydrochloride, and stimulated with 80 µM BzATP. Changes in intracellular Ca2+ following agonist application were detected as changes in maximum relative fluorescence (RLU) using FLIPRTETRA™. IC50 was calculated at 8.15 nM.

JNJ-54166060 (#J-125)

j-125

Alomone Labs JNJ-54166060 inhibits human P2X7 receptors:

J-125

Dose response curve of hP2X7 inhibition by JNJ-54166060 (#J-125). Cells were loaded with Fluo-8 NW dye, incubated with increasing concentrations of JNJ-54166060, and stimulated with 80 µM BzATP. Changes in intracellular Ca2+ following agonist application were detected as changes in maximum relative fluorescence (RLU) using FLIPRTETRA™. IC50 was calculated at 65.6 nM.

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