Anogen | 為您介紹IL 6＆TNF對治療的作用

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Anogen | 為您介紹IL 6＆TNF對治療的作用

2020.12.02

The researchers from Mount Sinai found that in severe COVID-19 cases, cytokines in the inflammatory pathway play a role in determining the severity and prognosis of the disease.

An inflammatory cytokine signature predicts COVID-19 severity and survival

Cytokine

They found that two cytokine levels were high; the IL-6 and TNF-a and those with higher levels of these two cytokines had more severe cases of COVID-19.

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TNF-a

TNF-a was also a strong predictor of poor outcome.

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Research

They found that two antiviral drugs were able to lower the cytokine levels; remesdivir and corticosteroid dexamethasone.

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Effect of IL 6 and TNF on treatment

Serum IL-6 and TNF-α levels should be considered in the management and treatment of patients with COVID-19 to stratify prospective clinical trials, guide resource allocation and inform therapeutic options.
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