BioVision-Cyclin-dependent kinase (CDK) Inhibitor

BioVision-Cyclin-dependent kinase (CDK) Inhibitor

2018.02.13

 BioVision’s Cyclin-Dependent Kinase (CDK) Inhibitors

Hello Customer,

Uncontrolled cellular proliferation mediated by the dysregulation of cell-cycle machinery and activation of cyclin-dependent kinases (CDKs) is the hallmark of cancer. Agents targeting CDKs have been considered as promising therapeutic targets in cancer treatment. Although the first-generation pan-CDK inhibitors failed in clinical trials because of their adverse events and low efficacy. Most recently, a new generation of selective CDK4/6 inhibitors, including Ribociclib, Abemaciclib and Palbociclib, have showed potent efficacy with tolerable safety in preclinical and clinical studies. Recent approval of Palbociclib (Ibrance®) by the U.S. Food and Drug Administration (FDA) for the treatment of ER-positive and HER2-negative breast cancer demonstrate that CDK inhibitors with high selectivity profiles can have clinical utility for therapy based on individual tumor genetics. BioVision is proud to offer >25 potent and selective CDK inhibitors including Palbociclib (PD0332991), Abemaciclib (LY-2835219), Dinaciclib, and Ribociclib for research.

Key Features:    

·        Highly Potent, Selective & Cell Permeable CDK Inhibitors

·        Many Options to Choose From

·        Cost-Effective

   A                                                                        B

     

A: Dinaciclib                                                                    B: Ribociclib

Check out the full list of CDK inhibitors that BioVision has to offer:

Product Name

Cat.No. 

Size

(R)-Perharidine-1

2615

1 mg, 5 mg

10Z-Hymenialdisine

2212

1 mg, 250 µg

Alsterpaullone

1897

1 mg, 5 mg

AMG-925

B1959

5 mg, 25 mg

Aminopurvalanol A

2205

1 mg, 5 mg

AT-7519 hydrochloride

2816

5 mg, 25 mg

Bohemine

B1040

10 mg, 50 mg

Butyrolactone I

1690

200 µg

CVT-313

B1137

5 mg, 25 mg

Dinaciclib

9537

5 mg, 25 mg

Flavopiridol

2090

1 mg, 5 mg

Kenpaullone

1904

1 mg

LY-2835219

B1039

10 mg, 50 mg

MSC-2530818

B1975

1 mg, 5 mg

NG52

9420

5 mg, 25 mg

NU6102

2313

1 mg, 5 mg

ON-013100

B1276

5 mg, 25 mg

PD-0332991 isethionate

9480

5 mg, 25 mg

PD-0332991

2843

5 mg, 25 mg

RGB-286638, free base

2886

5 mg, 25 mg

Ribociclib (LEE011)

9481

5 mg, 25 mg

RO-3306

2039

1 mg, 5 mg

Roscovitine

1950

1 mg, 5 mg

SNS-032

9490

5 mg, 25 mg

TG003

1905

5 mg, 25 mg

THZ1 (Free base)

9664

5 mg, 25 mg

THZ1 hydrochloride

9544

5 mg, 25 mg

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