alpha 5 beta 1 Integrin, Rabbit Antibody

ZZZZ_Status (Active, Disc) : Active

AA_Supplier Name : Biosensis

Alternative_Name (Other Names) :

Fibronectin receptor; CD49 antigen-like family member E; Integrin alpha-F; VLA-5; CD49e.

Antibody_Isotype
(Antibody only) : IgGkappa

Application_Details :

The antibody binds specifically to α5β1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The α5β1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.

Background_Info :

Clone_Name
(AB only, monoclonals) : M200 (Volociximab)

Datasheet_Link :

Description (Long Description) : 

NOT FOR THERAPEUTIC USE – This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques. The antibody binds specifically to α5β1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The α5β1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.

Expiry_Date : 

12 months after purchase if unopened.

Format (Form) : 

Liquid, PBS with 0.02% Proclin 300.

Immunogen (Antigen) :Heterodimeric α5β1Fc
fusion protein

Kit_Components :

MSDS (File name) :