ANTI HUMAN LXR ALPHA LIGAND BINDING DOMAIN

Brand

Iwai North America

Description

Liver X receptor alpha (LXRa, RLD-1; NR1H3) is a member of orphan nuclear receptor. LXRa activator is the naturally occurring compound 22(R)- hydroxycholesterol (22(R)-HC), 20(S)HC, 24-HC, 25- HC, 7a-HC. LXRa is expressed in the liver, kidney and spleen. LXRa has important role in regulating cholesterol metabolism. It is believed that LXR specific agonist may have important medical applications in the regulation of cholesterol homeostasis. LXRa forms heterodimer with RXR.

Application

IHCIPWB

Reactivity

Human

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