Biotinylated Bovine FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (SPR verified)

Source : 

MABSol® Biotinylated Bovine FcRn Heterodimer Protein, His,Avitag (SPR verified) (FCN-B82W3) is expressed from human HEK293 cells. It contains AA Ala 24 – Pro 298 (FCGRT) & Ile 21 – Leu 118 (B2M) (Accession # Q3T119-1 (FCGRT) & P01888-1 (B2M)).

Molecule : FcRn (FCGRT & B2M)

Synonyms : FcRn,FCGRT & B2M

Format : Powder

Category : MABSol® Biotin Labeled Proteins

Accession : NP_788830.1 (FCGRT) & NP_776318.1 (B2M)

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 34.5 kDa (FCGRT) and 11.6 kDa (B2M)

Characteristics :

Biotinylated Bovine FcRn Heterodimer Protein, His,Avitag (SPR verified), produced by co-expression of FCGRT and B2M, has a calculated MW of 34.5 kDa (FCGRT) and 11.6 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus, followed by

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

References :

(1) Goebl NA., et al., 2008, Mol. Biol. Cell 19 (12): 5490–505.
(2) Lee TY., et al., 2008, Clin. Cancer Res. 14 (5): 1487–93.
(3) Güssow D., et al., 1987, J. Immunol. 139 (9): 3132–8.
(4) Gorevic P.D., et al., 1986, Proc. Natl. Acad. Sci. U.S.A. 83:7908-7912.