Biotinylated Human Vitronectin / VTN Protein, Tag Free, ultra sensitivity (primary amine labeling)

Source : 

Biotinylated Human Vitronectin, Tag Free, primary amine labeling (VIN-H8113) is expressed from E.coli cells. It contains AA Asp 20 – Arg 398 (Accession # P04004-1).

Molecule : Vitronectin

Synonyms : VTN,V75,VN,Vitronectin,S-protein,Serum-spreading factor

Format : Powder

Category : MABSol® Biotin Labeled Proteins

Accession : NP_000629.3

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 43.2 kDa

Characteristics :

This protein carries no “tag”. The protein has a calculated MW of 43.2 kDa. The protein migrates as 47-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

References :

(1) Kohler S, et al. 2015 Thromb Haemost. 113(1):125-42. (2) Salazar-Peláez LM, et al. 2015. PLoS One. 10(3):e0119717. (3) Paulsson M, et al. 2015. J Cyst Fibros. 14(5):600-7.