Cynomolgus DR3 / TNFRSF25 Protein, Fc Tag

Source : 

Cynomolgus DR3, Fc Tag (TN5-C5257) is expressed from human 293 cells (HEK293). It contains AA Gln 20 – Gly 203 (Accession # G7NTB5-1).

Molecule : DR3 / TNFRSF25

Synonyms : TNFRSF25,DR3,APO3,DDR3,TNFRSF12,WSL,WSL1

Format : Powder

Category : Other Recombinant Proteins

Accession : N/A

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 46.3 kDa

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 46.3 kDa. The protein migrates as 50 kDa under reducing (R) condition (SDS-PAGE).

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

Description :

Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.

References :

(1) Kitson J., et al., 1996, Nature 384:372-375.
(2) Bodmer J.-L., et al., 1997, Immunity 6:79-88.
(3) Marsters S.A., et al., 1996, Curr. Biol. 6:1669-1676.