Cynomolgus IL-23 alpha & Mouse IL-12 beta Heterodimer Protein, His Tag&Tag Free
ILB-CM52W8
1mg
Brand
ACROBiosystems
Description
Source :
Cynomolgus IL-23A & Mouse IL-12B Heterodimer Protein, His Tag&Tag Free (ILB-CM52W8) is expressed from human 293 cells (HEK293). It contains AA Val 22 – Pro 189 (IL23A) & Met 23 – Ser 335 (IL12B) (Accession # A0A2K5TLV4-1 (IL23A) & P43432-1 (IL12B)).
Molecule : IL23A & IL12B
Synonyms : IL-23 alpha & IL-12 beta
Format : Powder
Category : Cytokines&Growth Factors
Accession : NP_001274588.1 | NP_001290173.1
Storage : -20℃
Shipping condition : Powder,RT
Molecular Weight : 20.3 kDa (IL23A) & 35.8 kDa (IL12B)
Characteristics :
Cynomolgus IL-23A & Mouse IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23 alpha and IL-12 beta, has a calculated MW of 20.3 kDa (IL-23 alpha) and 35.8 kDa (IL-12 beta). Subunit IL-23 alpha is fused with a polyhistidine tag
Endotoxin Level : Less than 1.0 EU per μg by the LAL method.
Buffer : PBS, pH7.4
Description :
Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
References :
(1) Oppmann B., et al., 2000, Immunity 13:715-725.
(2) Parham C., et al., 2002, J. Immunol. 168:5699-5708.
Application
Reactivity