Cynomolgus PVRIG Protein, Fc Tag
PVG-C5259
1mg
Brand
ACROBiosystems
Description
Source :
Cynomolgus PVRIG, Fc Tag (PVG-C5259) is expressed from human 293 cells (HEK293). It contains AA Thr 41 – Asp 171 (Accession # A0A2K5WVV8-1).
Molecule : PVRIG
Synonyms : C7orf15,C7orf15MGC138295,CD112R,MGC104322,MGC138297,MGC2463,PVRIG,CD112 receptor
Format : Powder
Category : Immune Checkpoint Proteins
Accession : XP_005549281.1
Storage : -20℃
Shipping condition : Powder,RT
Molecular Weight : 40.1 kDa
Characteristics :
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.1 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level : Less than 1.0 EU per μg by the LAL method.
Buffer : Tris with Glycine, Arginine and NaCl, pH7.5
Description :
Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The CD112R gene encodes a putative single transmembrane protein, which is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. Notably, the intracellular domain of phatases. The extracellular domain sequence of human and mouse CD112R have 65.3% similarity. CD112R may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
References :
(1) Xu F., et.al. 2017, Cancer Immunol Immunother., 66(10), 1367-1375.
(2) Zhu, Y., et.al. 2016, J. Exp. Med., 213,167-76.
Application
Reactivity