Cynomolgus / Rhesus macaque FGL1 Protein, Mouse IgG2a Fc Tag

Source : 

Cynomolgus / Rhesus macaque FGL1, Mouse IgG2a Fc Tag (FG1-C5250) is expressed from human 293 cells (HEK293). It contains AA Leu 23 – Ile 312 (Accession # G7N0K6-1).

Molecule : FGL1

Synonyms : FGL1,Hepassocin,HP-041,HFREP-1,LFIRE-1,HFREP1

Format : Powder

Category : Bio-Markers & CD Antigens

Accession : N/A

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 60.8 kDa

Characteristics :

This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 60.8 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

Buffer : 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5

Description :

Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1. The protective effect of fibrinogen-like protein 1 (FGL1) in liver injury has previously been reported. However, studies have shown that FGL1 may be a predictor of GC patients and a target for GC therapy. Immunocytochemical studies revealed that fgl1 selectively binds to defective spermatozoa in the cauda epididymidis. Northern blot analysis and in situ hybridization demonstrated the high expression of fgl1 in the principal cells of the proximal cauda epididymidis. Immunofluorescence analysis using mouse fibrotic lung tissues suggested that fibrotic regions showed increased expressions of Gtse1 and Fgl1, Gtse1 and Fgl1 are suggested to be novel targets for radiation-induced lung fibrosis.

References :

(1) Nagdas SK. 2016. Int J Biochem Cell Biol. 80:163-172.
(2) Jin H. 2018 Nov 7. J Mol Med (Berl).
(3) Zhang Y. 2018 Aug. Mol Med Rep. 18(2):1465-1472.