Cynomolgus Siglec-9 Protein, His Tag

Source : 

Cynomolgus Siglec-9, His Tag (SI9-C52H9) is expressed from human 293 cells (HEK293). It contains AA Gln 20 – Gly 350 (Accession # XP_005590140.1).

Molecule : Siglec-9

Synonyms : Siglec-9,SIGLEC9,CDw329,CD329

Format : Powder

Category : Other Recombinant Proteins

Accession : XP_005590140.1

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 38.0 kDa

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.0 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : 25 mM MES, 150 mM NaCl, pH5.5

Description :

siglec-9 (HGMW-approved symbol SIGLEC9) a member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF). SIGLEC9 shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%). This high degree of homology is also conserved in the extracellular Ig-like domains. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains。Siglec-9 with a hydrophobic signal peptide, an N-terminal Ig-likeV-type domain, two Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail.

References :

(1) Foussias G, et al. Genomics. 2000. 67(2):171-8.
(2) Liu YC, et al. Front Immunol. 2017. 8:1601.
(3) Angata T, et al. J Biol Chem. 2000. 275(29):22127-35.