Proteins and PeptidesCynomolgus TIM-3 / HAVCR2 Protein, His Tag

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TI3-C52H4

1mg

Brand

ACROBiosystems

Description

Source

Cynomolgus TIM-3, His Tag (TI3-C52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 22 – Arg 201 (Accession # EHH54703.1).

 

Molecule : TIM-3

 

Synonyms : HAVCR2,TIM3,TIMD3,FLJ14428,KIM3

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : EHH54703.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 21.6 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.6 kDa. The protein migrates as 30-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

 

References :

(1) Monney, L. et al., 2002, Nature, 415:536-541.
(2) Sabatos, CA. et al., 2003, Nat. Immunol., 4:1102-1110.
(3) Anderson, AC. et al., 2006, Curr. Opin. Immunol., 18:665-669.

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