Cynomolgus TSLP (R127A, R130S) Protein, His Tag

Source : 

Cynomolgus TSLP (R127A, R130S), His Tag (TSP-C52H4) is expressed from human 293 cells (HEK293). It contains AA Tyr 29 – Gln 159 (Accession # A0A2K5TXV0-1 (R127A, R130S)).

Molecule : TSLP

Synonyms : TSLP

Format : Powder

Category : Other Recombinant Proteins

Accession : XP_005557555.1

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 16.9 kDa

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.9 kDa. The protein migrates as 23-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.

References :

(1) Segawa R., et al., 2017, J. Dermatol. Sci. S0923-1811:31012-31015.
(2) Wang J., et al., 2008, Cell. Mol. Immunol. 5:99-106.
(3) Soumelis V., et al., 2002, Nat. Immunol. 3:673-680.