Goat anti-USP6 (aa142-155) Antibody

ZZZZ_Status (Active, Disc) : Active

AA_Supplier Name : Biosensis

Alternative_Name (Other Names) :

USP6; ubiquitin specific peptidase 6 (Tre-2 oncogene); HRP1; TRE17; TRE2; Tre-2; USP6-short; OTTHUMP00000125301; deubiquitinating enzyme 6; hyperpolymorphic gene 1; proto-oncogene TRE-2; tre-2 oncogene; ubiquitin carboxyl-terminal hydrolase 6; ubiquitin specific peptidase 6-; ubiquitin specific protease 6 (Tre-2 oncogene); ubiquitin thioesterase 6; ubiquitin thiolesterase 6; ubiquitin-specific protease USP6; ubiquitin-specific-processing protease 6

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Application_Details :

Western Blot: Preliminary experiments in Human Testis, Prostate and Placenta lysates gave no specific signal but low background at antibody concentration up to 1µg/ml.Immunofluorescence: Strong expression of the protein seen in the cytoplasm of A431 and U2OS cells. Recommended concentration: 10µg/ml.

Flow Cytometry: Flow cytometric analysis of A431 cells. Recommended concentration: 10ug/ml.

Peptide ELISA: antibody detection limit dilution 1:4000.

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(AB only, monoclonals) :

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Description (Long Description) : 

Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation

Expiry_Date : 

12 months after purchase if unopened.

Format (Form) : 

Liquid antibody. Supplied at 0.5 mg/mL in Tris saline, 0.02% sodium azide, pH 7.3 with 0.5% bovine serum albumin.

Immunogen (Antigen) :A synthetic peptide consisting of amino acids, C-HHIDLDVRTTLRNH

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