Proteins and PeptidesHuman VEGF-C / Flt4-L Protein, His Tag

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VEC-H4225

50ug

Brand

ACROBiosystems

Description

Source

Human VEGF-C, His Tag (VEC-H4225) is expressed from human 293 cells (HEK293). It contains AA Thr 103 – Arg 227 (Accession # AAH35212.1).

 

Molecule : VEGF-C

 

Synonyms : VEGFC,Flt4-L,VRP

 

Format : Powder

 

Category : Cytokines&Growth Factors

 

Accession : AAH35212.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 14.9 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.9 kDa. The protein migrates as 19-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Vascular endothelial growth factor C is also known as VEGFC, Flt4-L and VRP, it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs. Upon biosynthesis, VEGFC is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGFC is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor D (VEGF-D). VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Overexpression of VEGF-C causes lymphatics to enlarge possibly facilitates metastasis.

 

References :

(4) Orpana A, Salven P , 2003, Leuk. Lymphoma 43 (2): 219–24.
(5) Joukov V, et al., 1996, EMBO J., 15(2): 290-98.

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