Human VEGF-D Protein, His Tag

Source : 

Human VEGF-D, His Tag (VED-H5228) is expressed from human 293 cells (HEK293). It contains AA Phe 93 – Ser 201 (Accession # AAH27948).

Molecule : VEGF-D

Synonyms : FIGF,VEGFD

Format : Powder

Category : Cytokines&Growth Factors

Accession : AAH27948

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 13.4 kDa

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.4 kDa. The protein migrates as 19-22 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.

References :

(1) Leppanen V.M., et al., 2011, Blood 117:1507-1515.
(2) Yamada Y., et al., 1997, Genomics 42 (3): 483–8.
(3) Achen MG., et al., 1998, Proc. Natl. Acad. Sci. U.S.A. 95 (2): 548–53.
(4) Yasuoka H., et al., 2005, Mod. Pathol. 18 (8): 1127–33.