Human Vitronectin / VTN Protein, Tag Free
VIN-H5119
1mg
Brand
ACROBiosystems
Description
Source :
Human Vitronectin, Tag Free (VIN-H5119) is expressed from E.coli cells. It contains AA Asp 20 -Arg 398 (Accession # P04004-1).
Molecule : Vitronectin
Synonyms : VTN,V75,VN,Vitronectin,S-protein,Serum-spreading factor
Format : Powder
Category : Other Recombinant Proteins
Accession : NP_000629.3
Storage : -20℃
Shipping condition : Powder,RT
Molecular Weight : 43.2 kDa
Characteristics :
This protein carries no “tag”. The protein has a calculated MW of 43.2 kDa. The protein migrates as 48-50 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin Level : Less than 1.0 EU per μg by the LAL method.
Buffer : 20 mM Tris-HCl, containing sucrose and Arginine, pH8.0
Description :
Vitronectin is also known as S-protein, VN, VTN, V75. Vitronectin, a multifunctional glycoprotein, is involved in coagulation, inhibition of the formation of the membrane attack complex (MAC), cell adhesion and migration, wound healing, and tissue remodeling. The primary cellular source of vitronectin is hepatocytes. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococcal binding to soluble and immobilised vitronectin and to Factor H, respectively. In addition, Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
References :
(1) Kohler S, et al. 2015 Thromb Haemost. 113(1):125-42. (2) Salazar-Peláez LM, et al. 2015. PLoS One. 10(3):e0119717. (3) Paulsson M, et al. 2015. J Cyst Fibros. 14(5):600-7.
Application
Reactivity