Mouse monoclonal antibody to rat p75NTR [MC192], Saporin-conjugated

ZZZZ_Status (Active, Disc) : Active

AA_Supplier Name : Biosensis

Alternative_Name (Other Names) :

Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR

Antibody_Isotype
(Antibody only) : IgG1

Application_Details :

1. To specifically target and eliminate rat cells expressing p75NTR in vivo. MC192-saporin has been used to selectively lesion cholinergic neurons of basal forebrain to create an animal model to study Alzheimer’s disease.
2. To be used as a model for gene delivery into neurons.

Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Background_Info :

Clone_Name
(AB only, monoclonals) : MC192

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=1606

Description (Long Description) : 

MC192-saporin is an antibody conjugate comprising of the monoclonal antibody MC192 against rat p75^NTR, the nerve growth factor receptor, chemically conjugated via a reducible disulfide bridge to the ribosome-inactivating protein saporin, purified from saponaria officinalis. Unconjugated saporin is incapable of entering the cells due to the apparent lack of ligand. Upon specific binding via MC192 to the cells expressing p75^NTR, saporin transverses the cell membrane leading to lesion of neurochemically defined neuronal populations. The targets of MC192-Saporin are p75^NTR-expressing cells including cholinergic neurons of the basal forebrain, cerebellar Purkinje cells, medial septum, diagonal band of Broca, Nucleus basalis of Meynert and some tumour cells. MC192-saporin has been used in the study of learning and memory and its primary application is in vivo, MC192-saporin is specific for applications in rat. The antibody does not cross-react with human or mouse p75^NTR receptors.

Expiry_Date : 

12 months from receipt when stored at -80°C (undiluted conjugate only).

Format (Form) : 

Liquid. Provided as 1 mg/mL conjugate in PBS, pH 7.2-7.6, without preservative.

Immunogen (Antigen) :Rat NGF receptor (p75NTR)

Kit_Components :

MSDS (File name) :