Nitazoxanide (250 mg)

ZZZZ_Status (Active, Disc) : Active

AA_Supplier Name : Biosensis

Alternative_Name (Other Names) :

NTZ; CAS 55981-09-4

Antibody_Isotype
(Antibody only) :

Application_Details :

NTZ demonstrates IC50 values of 2.5 and 10 uM for Giardia and Cryptosporidium, respectively. Additionally, NTZ kills replicating and nonreplicating M. tuberculosis with an IC50 value of 1 uM, while seemingly evading the development of resistance (6).

Background_Info :

Clone_Name
(AB only, monoclonals) :

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=1750

Description (Long Description) : 

Pharmacology: Nitazoxanide is a clinically useful antiparasitic agent (1). It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, hepatitis B and C, RSV, coronavirus, dengue and others (2). Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases (3). Antiviral activity involves activation of protein kinase activated by double- stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) (4). Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC), targeting peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of β-catenin (5). PubChem CID: 41684.

Product is sold for research use only. Not for human therapeutic use or for medicinal purposes.

InChI
InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

InChI Key
YQNQNVDNTFHQSW-UHFFFAOYSA-N

Canonical SMILES
CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]

Expiry_Date : 

Store desiccated as supplied at -20C for up to 2 years. Store solutions at -20C for up to 1 month. Prevent multiple freeze-thaw cycles.

Format (Form) : 

Dry, white powder.

Immunogen (Antigen) :

Kit_Components :

MSDS (File name) :