Porcine FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR verified)

Source : 

Porcine FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR verified) (FCM-P5280) is expressed from human 293 cells (HEK293). It contains AA Asp 16 – Ser 289 (FCGRT) & Val 21 – His 118 (B2M) (Accession # Q6XAV9-1 (FCGRT) & Q07717-1 (B2M)).

Molecule : FcRn (FCGRT & B2M)

Synonyms : FcRn,FCGRT & B2M

Format : Powder

Category : MABSol® Fc Receptors

Accession : N/A

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 32.3 kDa (FCGRT) & 12.8 kDa (B2M)

Characteristics :

Porcine FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR verified), produced by co-expression of FCGRT and B2M, has a calculated MW of 32.3 kDa (FCGRT) and 12.8 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus and subun

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

References :

(1) Goebl NA., et al., 2008, Mol. Biol. Cell 19 (12): 5490–505.
(2) Lee TY., et al., 2008, Clin. Cancer Res. 14 (5): 1487–93.
(3) Güssow D., et al., 1987, J. Immunol. 139 (9): 3132–8.
(4) Gorevic P.D., et al., 1986, Proc. Natl. Acad. Sci. U.S.A. 83:7908-7912.