Rabbit Anti-ACE2 Antibody (DISCONTINUED)

ZZZZ_Status (Active, Disc) : Discontinued

AA_Supplier Name : Biosensis

Alternative_Name (Other Names) :

ACE2 Antibody: ACEH, Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACEH, SARS-CoV receptor, SARS-CoV-2 receptor

Antibody_Isotype
(Antibody only) : IgG

Application_Details :

WB: 4 µg/mL; IHC: 2 µg/mL; IF: 20 µg/mL. Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in human, mouse and rat samples; Immunofluorescence in human samples. All other applications and species not yet tested.

Background_Info :

ACE2 Antibody: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. Homology modeling shows 2019-nCoV has a similar receptor-binding domain structure as SARS-CoV, which suggests COVID-19 (2019-nCoV) may use ACE2 as a receptor in humans for infection. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

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(AB only, monoclonals) :

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Description (Long Description) : 

SARS-CoV Spike Antibody: A novel coronavirus has been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

Expiry_Date : 

12 months after purchase if unopened.

Format (Form) : 

Liquid ,ACE2 Antibody is supplied in PBS containing 0.02% sodium azide. Conc.1 mg/mL

Immunogen (Antigen) :ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2.

The immunogen is located within amino acids 150 – 200 of ACE2.

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