Rhesus macaque GITR / TNFRSF18 Protein, Fc Tag

Source : 

Rhesus macaque GITR, Fc Tag (GIR-C5255) is expressed from human 293 cells (HEK293). It contains AA Gln 26 – Glu 161 (Accession # F7DDV8).

Molecule : GITR

Synonyms : AITR,GITR,TNFRSF18,CD357

Format : Powder

Category : Immune Checkpoint Proteins

Accession : N/A

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 41.3 kDa

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.3 kDa. As a result of glycosylation, the protein migrates as 48 kDa under reducing (R) condition, and 85 kDa under non-reducing (NR) condition (SDS-PAGE).

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

Description :

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

References :

(1) Gurney A.L., et al., 1999, Curr. Biol. 9:215-218.
(2) Park MS., et al., 2007, Yonsei Med J 48 (5): 839-46.