SARS-CoV-2 (COVID-19) S protein (R683A, R685A), His Tag, Super stable trimer (MALS & NS-EM verified)
SPN-C52H9
500ug
Brand
ACROBiosystems
Description
Source :
SARS-CoV-2 S protein (R683A, R685A), His Tag, Super stable trimer (MALS & NS-EM verified) (SPN-C52H9) is expressed from human 293 cells (HEK293). It contains AA Val 16 – Pro 1213 (Accession # QHD43416.1 (R683A, R685A)) trimer Design.
Molecule : S protein
Synonyms : S protein,Spike glycoprotein,S glycoprotein,COVID-19
Format : Powder
Category : Viral Proteins
Accession : QHD43416.1 (R683A, R685A)
Storage : -20℃
Shipping condition : Powder,RT
Molecular Weight : 138.0 kDa
Characteristics :
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 138.0 kDa. The protein migrates as 180-220 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level : Less than 1.0 EU per μg by the LAL method.
Buffer : 50 mM Tris, 150 mM NaCl, pH5.5
Description :
It’s been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
References :
(1) Wan Y, et al. J Virol. 2020. pii: JVI.00127-20.
(2) Benvenuto D, et al. J Med Virol. 2020.
(3) Chang CY, et al. AMB Express. 2020. 10(1):20.
Application
Reactivity