Vaccinia Virus B18R Protein, His Tag

Source : 

Vaccinia Virus B18R, His Tag, His 20 – Glu 351 (Accession # P25213), was produced in human 293 cells (HEK293) at ACROBiosystems.

Molecule : B18R

Synonyms : B18R

Format : Powder

Category : Viral Proteins

Accession : N/A

Storage : -20℃

Shipping condition : Powder,RT

Molecular Weight : 40.3 kDa

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 40.3 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

Buffer : PBS, pH7.4

Description :

B18R is a type I interferon (IFN)-binding protein and it is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus, which contains two Ig-like C2-type domains and one Ig-like V-type domain. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R counteracts the antiviral effects of host IFN-alpha/beta. Also, B18R acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.

References :

(1) Alcami A., et al., 2000, J. Virol. 74:11230-11239.
(2) Waibler Z., et al., 2009, J. Virol. 83:1563-1571.