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β-Synuclein – the Forgotten Synuclein, Or Is It?
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Synaptic loss, or the degeneration of synapses, is known to be one of the hallmarks of Alzheimer’s Disease (AD) (Jackson et al., 2019). β-synuclein, a member of the synuclein family of proteins, is found in abundance in presynaptic terminals. Unlike α-synuclein and sometimes overlooked, recent research suggests β-synuclein to be an early diagnostic marker for AD in CSF (Halbgebauer et al., 2020).
NEW β-Synuclein Antibodies to Advance your Research
Biosensis has introduced two antibodies to β-synuclein, made in mouse and rabbit. Both antibodies are an excellent choice for use in Immunohistochemistry and Western Blotting, complementing our well-established sheep antibody to β-synuclein. Our β-synuclein antibodies provide maximum flexibility in experimental design and high-quality results in human and rodent samples.
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Analysis of β-synuclein expression in rat cerebellum section by Immunohistochemistry. β-synuclein (red) was detected with rabbit antibody R-2105-100 (1:1,000), and sections co-stained with chicken antibody to parvalbumin (C-1814-50, green, 1:5,000). Blue: Hoechst nuclear stain. The β-synuclein antibody detects protein concentrated in synaptic regions, while the parvalbumin antibody labels the perikarya and dendrites of Purkinje cells and interneurons in the molecular layer of the cerebellum.
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Western blot analysis of β-synuclein expression in tissue homogenates using mouse antibody M-2106-100 (green, 1:1,000). Lane 1: MWM; Lane 2: rat cortex; Lane 3: rat cerebellum; Lane 4: mouse cortex; Lane 5: mouse cerebellum; Lane 6: cow cortex; Lane 7: cow cerebellum. A strong band at about 17 kDa corresponds to β-synuclein protein.
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Good luck with your research,
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