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Tackling the Surging Arbovirus
Threat: Strategic Research
Directions and Rapid
Solutions from Sino Biological
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Arboviruses such as Dengue virus (DENV), Zika virus (ZIKV), and Chikungunya virus (CHIKV) pose a growing global threat, yet vaccine development is hindered by antibody-dependent enhancement (ADE). Sub-neutralizing antibodies targeting the exposed fusion loop on monomeric envelope (E) protein can worsen infection. Stabilized E-protein dimers solve this: their native conformation masks the fusion loop while displaying potent neutralizing epitopes for robust, safe immunity.
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Sino Biological offers a comprehensive range of high-quality recombinant arbovirus E proteins—including SEC-MALS validated, highly stable E dimers—engineered to meet the exacting standards of structure-guided vaccine design.
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Sino Biological’s Specialized Arbovirus Toolbox
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Extensive Coverage of Virus Types
CHIKV, DENV, ZIKV, WNV, CCHFV, RVFV, YFV, TBEV, SFTSV, CHPV, HRTV, POWV, DTV, etc.
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Designed for Vaccine Development
Stabilized E protein dimers effectively hides the dangerous fusion loop to circumvent ADE.
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SEC-MALS Validated
The native, dimeric conformation of E protein dimers is validated by SEC-MALS.
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Covers all four DENV serotypes
E protein dimers of DENV-1, DENV-2, DENV-3, and DENV-4
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Featured DENV E Dimer Antigens
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Dengue virus (DENV) E Dimer Protein
(type 1, strain US/Hawaii/1944)
Cat#: 40531-V08H1
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SEC-MALS Validated
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The purity of DENV E Dimer Protein was more than 90% and the molecular weight of this protein is around 95.5 kDa verified by SEC-MALS.
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Dengue virus (DENV) E Dimer Protein
(type 2, strain New Guinea C/PUO-218 hybrid)
Cat#: 40471-V08H
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SEC-MALS Validated
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The purity of DENV E Dimer Protein was more than 95% and the molecular weight of this protein is around 99.7 kDa verified by SEC-MALS.
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Dengue virus (DENV) E Dimer Protein
(type 3, strain Philippines/H87/1956)
Cat#: 40532-V08H2
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SEC-MALS Validated
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The purity of DENV E Dimer Protein was more than 95% and the molecular weight of this protein is around 95.1 kDa verified by SEC-MALS.
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Dengue virus (DENV) E Dimer Protein
(type 4, strain Philippines/H241/1956)
Cat#: 40533-V08H1
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SEC-MALS Validated
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The purity of DENV E Dimer Protein was more than 95% and the molecular weight of this protein is around 85.5 kDa verified by SEC-MALS.
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More Featured Arbovirus Antigens
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Virus
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Cat#
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Molecule
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Strain
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Expressed Host
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Purity
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CHIKV
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CC176-V2208H
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CHIKV-E1&E2
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UVE/CHIKV/2024/RE/CNR_79903
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HEK293 Cells
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> 90%
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CHIKV
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40440-V08B
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CHIKV-E2
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strain SL-CK1
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Baculovirus-Insect Cells
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> 90%
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ZIKV
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40544-V07H
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ZIKV-NS1
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ZikaSPH2015
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HEK293 Cells
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> 95%
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ZIKV
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40543-V08B4
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ZIKV-E
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ZikaSPH2015
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Baculovirus-Insect Cells
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> 90%
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DENV
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40263-V07H
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DENV-NS1
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Strain New Guinea C
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HEK293 Cells
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> 90%
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DENV
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40471-V08B
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DENV-E
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type 2, strain New Guinea C/PUO-218 hybrid
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Baculovirus-Insect Cells
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> 80%
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WNV
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40346-V07H
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WNV-NS1
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Lineage 1, strain NY99, Isolate 385-99
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HEK293 Cells
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> 95%
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Antibodies for Arbovirus Detection
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Virus
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Cat#
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Molecule
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Strain
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Application
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Antibody type
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ZIKV
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40544-MM03
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ZIKV-NS1
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ZikaSPH2015
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ELISA(Cap)
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Mouse MAb
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ZIKV
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40544-MM10
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ZIKV-NS1
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ZikaSPH2015
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ELISA(Det)
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Mouse MAb
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ZIKV
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40544-MM15
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ZIKV-NS1
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ZikaSPH2015
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WB,ELISA
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Mouse MAb
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ZIKV
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40544-R201
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ZIKV-NS1
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ZikaSPH2015
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ELISA
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Rabbit MAb
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ZIKV
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40544-MM10-H
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ZIKV-NS1
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ZikaSPH2015
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ELISA
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Mouse MAb
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DENV
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40263-MM02
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DENV-NS1
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Strain New Guinea C
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ELISA
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Mouse MAb
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DENV
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40263-MM12
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DENV-NS1
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Strain New Guinea C
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ELISA
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Mouse MAb
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DENV
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40263-T62
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DENV-NS1
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Strain New Guinea C
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WB,ELISA
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Rabbit PAb
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DENV
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40471-T62
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DENV-E
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type 2, strain New Guinea C/PUO-218 hybrid
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WB,ELISA
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Rabbit PAb
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