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MedChemExpress (MCE) 提供多元的高品質研究化學品和生物化學品，包括用於實驗室和科學用途的新型生物活性化合物、染劑、胜肽和天然化合物。
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• 超過 50,000 種生物活性分子化合物的庫存
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• 超過針對20多種訊號傳遞路徑中的500多種關鍵目標蛋白的化合物
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• 產品均附上品質報告書(LC/MS、NMR 和 HPLC)
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• 每月發佈超過1000 種最新的產品
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• 提供詳細Datasheet的資訊
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• 高純度和有競爭力的價格
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• 快速到貨
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CAS No.: 2488952-40-3
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Research Area: EED Inhibitor/Lymphoma
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A potent and orally active embryonic ectoderm development (EED) inhibitor with an IC50 of 0.2 nM.
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Efficaciously inhibits Pfeiffer and KARPAS422 lymphoma cancer cells with IC50 values of 20 pM and 0.5 nM, respectively.
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Significantly induces tumor regression in KARPAS422 xenograft mouse models.
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Solubility: DMSO : 125 mg/mL (260.67 mM; Need ultrasonic)
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CAS No.: 859525-02-3
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Research Area: Glucokinase Activator/Type 1 and 2 Diabetes
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An orally active and liver-selective glucokinase (GK) activator.
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Increases glucose metabolism in rat hepatocytes with EC50 values of 2.39 μM and 2.64 μM for lactate and glycogen, respectively.
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Reduces blood glucose, lactate and triglyceride concentrations in ob/ob mouse models with severe diabetes.
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Solubility: DMSO : 125 mg/mL (274.35 mM; Need ultrasonic)
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CAS No.: 371217-32-2
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Research Area: ASIC-3 Inhibitor/Depression and Pain
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A potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM.
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Dose-dependently inhibits all ASIC currents (IC50s of 2-30 µM).
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Shows fully analgesic effects in Complete Freund’s adjuvant (CFA)-induced inflammatory thermal hyperalgesia rat models.
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Solubility: DMSO : 125 mg/mL (314.42 mM; Need ultrasonic)
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CAS No.: 2758364-02-0
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Research Area: BRCA2-RAD51 Interaction Inhibitor/Cancer
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A selective orthosteric inhibitor of BRCA2-RAD51 interaction with a Kd of 366 nM.
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Dose-dependently decreases RAD51 nuclear foci and inhibits DNA repair.
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Induces cell-cycle arrest and cell apoptosis.
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Solubility: DMSO : 125 mg/mL (236.31 mM; Need ultrasonic)
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CAS No.: 1375752-78-5
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Research Area: mGluR5 Silent Allosteric Modulator/Alzheimer’s Disease
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An orally active and BBB penetrable mGluR5 silent allosteric modulator (SAM) with a Ki value of 0.6 nM.
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Prevents amyloid-β oligomer (Aβo) mediated toxicity and Aβo-induced signal transduction in brain slices.
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Rescues memory deficits and synaptic depletion in Alzheimer’s disease transgenic mouse models.
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Solubility: DMSO : 100 mg/mL (266.79 mM; Need ultrasonic)
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MCE分子膠化合物庫
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| 靶向蛋白質降解Targeted protein degradation(TPD)是一種新型且有潛力的新藥發現和開發方法，其顯示出治療具有“非藥性”致病蛋白靶標的疾病和克服抗藥性的巨大潛力。分子膠和PROTACs都是最受關注的靶向蛋白降解劑。
分子膠是小分子降解劑，主要誘導 E3 ligase與靶蛋白之間的相互作用並形成復合物，進而導致蛋白質泛素化和隨後的蛋白酶體降解。與 PROTAC 相比，分子膠通常具有更有利的類藥物特性，如: 更低的分子量、更高的細胞滲透性和更好的吸收，分子膠正在成為一種有前途的新治療策略。
MCE 提供獨特的 30 多種針對各種蛋白質的分子膠，MCE分子膠化合物庫是進行科學研究和疾病機制研究的最強工具。 |
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最新文獻引用MCE產品
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Nature.
2022 Dec;612(7940):555-563.
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Science.
2022 Dec 2;378(6623):eabo5503.
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Cell.
2022 Nov 10;185(23):4347-4360.e17.
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Cell.
2022 Dec 8;185(25):4801-4810.e13.
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