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Online View
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Angiopoietin-2 (ANGPT2) is a ligand of the receptor tyrosine kinase TIE2 (TEK). In conjunction with vascular endothelial growth factor (VEGF), ANGPT2-TIE2 signaling induces vascular sprouting. Inhibition of ANGPT2 shows promising results in preventing tumor angiogenesis, tumor growth, and metastasis in preclinical models, making it an attractive candidate to target in cancer.
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Angiopoietins are a family of secreted factors consisting of ANGPT1, ANGPT2, ANGPT3 (ANGPTL1), ANGPT4, ANGPT5 (ANGPTL3), ANGPTL2, ANGPTL4, ANGPTL5, ANGPTL6, and ANGPTL7. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. ANGPT2 is highly upregulated at the early stages of tumor progression to drive neovessel formation. Conventional anti-VEGF therapies primarily target immature blood vessels in tumors. The combinational targeting of both ANGPT2 and VEGF pathways is now expected to improve clinical efficacy by expanding the target vessel population. Sino Biological has developed high-quality reagents to support the study of the ANGPT2/TIE2 signaling.
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ANGPT2/TIE2 Pathway Proteins
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Sino Biological has developed a panel of high activity ANGPT2 and TIE2 proteins from various species for studying the biology of the ANGPT2/TIE2 pathway.
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• Recommended ANGPT2/TIE2 Proteins
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Please visit #Sino Biological to search for these products.
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Molecule
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Catalog #
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Species
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Tag
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Expressed Host
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Activity
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ANGPT2
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10691-H02H
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Human
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C-hFc
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HEK293 Cells
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Active
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ANGPT2
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10691-H38H1
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Human
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C-mFc
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HEK293 Cells
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ANGPT2
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70034-D07H
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Canine
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N-His
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HEK293 Cells
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Active
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ANGPT2
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90026-C01H
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Cynomolgus, Rhesus
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N-hFc
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HEK293 Cells
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Active
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ANGPT2
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90026-C07H
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Cynomolgus, Rhesus
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N-His
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HEK293 Cells
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Active
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ANGPT2
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90026-C08H
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Cynomolgus, Rhesus
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C-His
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HEK293 Cells
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Tie2
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10700-H03H
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Human
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C-hFc & His
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HEK293 Cells
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Active
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Tie2
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10700-H08H
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Human
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C-His
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HEK293 Cells
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Active
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Tie2
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10700-H08H-B
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Human
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C-His
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HEK293 Cells
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Tie2
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10700-H20B1
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Human
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N-GST & His
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Insect Cells
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Active
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Tie2
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51087-M02H
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Mouse
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C-hFc
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HEK293 Cells
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Active
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Tie2
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51087-M08H
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Mouse
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C-His
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HEK293 Cells
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Active
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Tie2
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51087-M20B1
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Mouse
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N-GST & His
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Insect Cells
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Active
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Tie2
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80063-R02H
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Rat
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C-hFc
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HEK293 Cells
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Active
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Tie2
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90292-C02H
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Cynomolgus
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C-hFc
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HEK293 Cells
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Active
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Tie2
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90292-C08H
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Rhesus
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C-His
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HEK293 Cells
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• Other Related Proteins
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ANGPT2/TIE2 Pathway Antibodies
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Sino Biological has developed a comprehensive panel of antibodies targeting ANGPT2/TIE2 and related molecules, which can be used in FCM, ELISA, WB, ICC/IF, and IP. ELISA kits and ELISA pair sets are also available.
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+1-215-583-7898
1400 Liberty Ridge Drive, Suite 101, Wayne, PA 19087 
