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Novel Investigational Tools for Diabetes Mellitus
As understanding of the underlying pathophysiology and metabolic abnormalities leading to the development of type-2 diabetes mellitus has increased, novel pharmacologic approaches have been developed to better manage this disease. Since improved glycemic control reduces long-term microvascular complications, new peptide-based agents that act on insulin secretion and regulation have been used. Abbiotec offers over 100 antibodies and peptides to investigate diabetes with these agents and their targets.
Download our Diabetes Product Brochure here.
GLP-1 and GLP-2 Antibodies Peptides ELISA Pairs
Incretins are insulinotropic peptides that augment insulin secretion and suppress glucagon secretion. Glucagon-like peptide 1 (GLP-1) is the incretin with dominant biological activity, which is produced by the L cells of the intestinal mucosa from the same prohormone as glucagon.
Exendins 1, 2, 3 and 4 Antibodies Peptides ELISA Pairs
Exendin-4, a GLP-1-like peptide from the Gila monster venom, is a naturally occurring long-acting GLP-1 receptor antagonist. An exendin-4 product (Exenatide) has been FDA-approved for type-2 diabetes treatment in controlling glycemic response and inducing weight loss.
Amylin Antibodies Peptides
Amylin is a 37-aa peptide co-secreted with insulin in response to meal ingestion. Pramlintide is a synthetic analog of amylin approved by the FDA as adjuvant therapy in type-1 and type-2 diabetes, acting by decreasing appetite, slowing gastric emptying and glucagon secretion.
Contact our Customer Service Dept for comprehensive listing, availability, and new products to be released.
SPECIAL OFFER – Until October 31, 2021 – Save 20% on Diabetes Antibodies and Peptides. Use promo code ENEWS0921 at time of order. Terms and conditions apply.
LATEST PRODUCT CITATIONS – For a complete list of product citations, refer to the citation webpage.
Cat. No. 250505 Glucosylceramide Synthase Antibody for WB in rat skeletal muscle
Obanda DN. et al. 2014. Nutrition. 30(0): S59-S66. PMID 24985108. Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells.
Cat. No. 250659 Gastrin Receptor Antibody for WB in human adenocarcinima cells
Rao SV. et al. 2017. BMC Cancer. PMID 28109268. Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells.
Cat. No. 250668 GIP Antibody for IHC in frozen sections of mouse intestine
Nagatake T. et al. 2014. PLoS ONE. 9(3): e90638. PMID 24603700. Enteroendocrine cells are specifically marked by cell surface expression of claudin-4 in mouse small intestine.
Cat. No. 250892 Transthyretin Antibody for WB in anorexic rat hypothalamus, CSF and blood
Zheng F. et al. 2016. Sci Rep. PMID 27053000. Central transthyretin acts to decrease food intake and body weight.
Cat. No. 252007 ADIPOR1 Antibody for IHC in human renal carcinoma patients
Ito R. et al. 2017. PLoS ONE. PMID 28178338. The impact of obesity and adiponectin signaling in patients with renal cell carcinoma: a potential mechanism for the “obesity paradox”.
Cat. No. 254537 Leptin Receptor Antibody for WB and IHC in mouse brain
Barrios-Correa A. et al. 2018. Biomed Res Int. PMID 29789785. Chronic intake of commercial sweeteners induces changes in feeding behavior and signaling pathways related to the control of appetite in BALB/c mice.
Cat. No. 350171 Exendin-4 Peptide for porcine ESC differentiation media
Vassiliev I. et al. Stem Cell Biology & Res. 2014. ISSN 2054-717X. Effect of cytochalasin types on the production of heterozygous parthenogenetic porcine embryos and the isolation of putative parthenogenetic embryonic stem cells.
ABBIOTEC is a biotech company founded in 2007 in San Diego, California, a renowned world-class Life Sciences cluster that hosts more than 1,500 research labs and biotech companies. We are focused on developing, producing and commercializing next generation antibodies and unique reagents for the Life Sciences research community including the diagnostic and pharmaceutical markets.
ABBIOTEC offers years of expertise making antibodies and assay kits for catalog products to the scientific and biotech community. With our recently upgraded animal facility, we offer polyclonal antibody production in small and large animals (rabbits, goats, llama) as well as monoclonal antibody production (mice and rats). Because peptide chemistry is an essential tool to biology, we offer custom peptide synthesis services for research-grade peptides.
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