Abcam | 神經標記物指南

Abcam | 神經標記物指南

2023.11.29

人類大腦仍然是科學上的一大謎團,許多研究人員仍在試圖研究神經系統的分子機制和細胞過程,而預防和有效治療阿茲海默症以及帕金森氏症等神經系統疾病是仍是非常重大的醫學挑戰。

 

神經元和神經膠質細胞表達獨特的轉錄因子、酵素、細胞骨架蛋白和受體。依據abcam的使用指南,輕鬆挑選您最佳的實驗標記。

 

Neural Markers

Cell type

Markers

Neuroepithelial cells

Nestin, SOX2, Notch1, HES1, HES3, E-cadherin, Occludin.

Radial glia

Vimentin, Nestin, PAX6, HES1, HES5, GFAP, GLAST, BLBP,

TN-C, N-cadherin, SOX2.

Intermediate progenitors

TBR2, MASH1/Ascl1.

Immature neurons

Doublecortin, Beta III tubulin, NeuroD1, TBR1, Stathmin 1.

Oligodendrocyte precursor cells

PDGF receptor alpha, NG2.

Mature oligodendrocytes

Olig 1, Olig 2, Olig 3, MBP, OSP, MOG, SOX10.

Schwann cells

MPZ, NCAM, GAP43, S100, P75NTR.

Astrocytes

GFAP, EAAT1/GLAST, EAAT2/GLT-1, Glutamine synthetase, S100 beta, ALDH1L1.

Microglia

TMEM119, CD11b, CD45, Iba1, CX3CR1, F4/80, CD68, CD40.

Mature neurons

NeuN, MAP2, 160 kDa neurofilament medium,

200kDa neurofilament heavy, Synaptophysin, PSD95.

Glutamatergic neurons

VGLUT1, VGLUT2, NMDAR1, NMDAR2B, Glutaminase, Glutamine synthetase.

GABAergic neurons

GABA transporter 1, GABAB receptors 1 and 2, GAD65, GAD67.

Dopaminergic neurons

Tyrosine hydroxylase, Dopamine transporter, FOXA2, GIRK2, Nurr1, LMX1B

Serotonergic neurons

Tryptophan hydroxylase, Serotonin transporter, Pet1.

Cholinergic neurons

Choline acetyltransferase, Vesicular acetylcholine transporter, Acetylcholinesterase

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