Choosing the FAP Homodimer with High Enzyme Activity for Solid Tumor Study
FAP is a promising therapeutic target for solid tumor due to its unique enzymatic activity and selective expression in tumor microenvironment, which is enzymatically active as a homodimer.
ACROBiosystems has developed a series of active FAP homodimer protein products. The homodimer purity, binding capacity and enzyme activity have been verified by SEC-MALS, ELISA and enzyme assay respectively, and the specific enzyme activity is greater than 8000 pmol/min/µg.
>> The specific enzyme activity is greater than 8000 pmol/min/µg.
Measured by its ability to convert the substrate benzyloxycarbonyl-Gly-Pro-7-amido-4-methylcoumarin (Z-GP-AMC) to Z-Gly-Pro and 7-amino-4-methylcoumarin (AMC). The specific activity is >8000 pmol/min/µg.