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Human neutralizing antibody co-developed by ACROBioystems can block SARS-CoV-2 mutants
On June 7th, an article Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody libraries was published on the preprint platform bioRixiv. In this article, scientists from Zhejiang University School, East China Normal University, SymRay Biopharma Inc. and ACRObiosystems Inc. isolated human neutralizing antibodies from the patient-derived antibody libraries and some of them were proved to have the potential to become therapeutic agents against SARS-CoV-2 and its mutants in this global pandemic1.
ACROBiosystems has developed anti-SARS-CoV-2 S protein RBD neutralizing antibody and Nucleocapsid antibody. In addition, kit products for neutralizing antibody screening and antibody titer assay, and recombination proteins are provided to accelerate the anti-SARS-CoV-2 drugs and vaccines R&D.
RBD and N antibody
>> Human antibodies isolated from the serum of recovered patients
- As a control to develop various assays
- Accelerating SARS-COV-2 diagnostic kits, therapeutics and vaccines R&D
Relevant products：
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Molecule
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Cat.No.
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Product description
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Status
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S protein RBD
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SAD-S35
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Anti-SARS-CoV-2 neutralizing antibody, Human IgG1
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Launched
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Nucleocapsid protein
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NUN-S41
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Anti-SARS-CoV-2 Nucleocapsid Antibody, Human IgG1
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Launched
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Antibody titer assay solution
>> Multiple antibody titer assay kits
- High throughput, high flexibility, high reproducibility, high sensitivity and high stability
- Various assay kits available for different application of antibody titer measurement
Relevant products:
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Molecule
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Cat.No.
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Product description
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Status
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S1 protein
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TAS-K001
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Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike protein S1)
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Launched
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S protein RBD
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TAS-K002
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Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike protein RBD)
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Launched
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S protein RBD
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TAS-K003
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Anti-SARS-CoV-2 neutralizing antibody titer serologic assay kit
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Launched
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S1 protein/
RBD protein
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TAS-K006
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Detecting the total SARS-CoV-2 antibody ELISA kit
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Coming soon
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Nucleocapsid protein
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TAS-K009
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Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Nucleocapsid protein)
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Coming soon
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S protein
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TAS-K010
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Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Spike protein)
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Coming soon
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Antibody screening solution
>> Inhibitor screening kit/pre-coupled magnetic beads/pre-coated plates
- High throughput inhibitor screening kit can screen 96 or 480 candidate antibodies simultaneously
- Ready-to-use beads and plates can improve the efficiency of neutralizing antibody screening
Relevant products：
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Molecule
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Cat.No.
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Product description
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Status
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S protein RBD
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EP-105
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SARS-CoV-2 Inhibitor Screening Kit
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Launched
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S1 protein
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MBS-K001
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SARS-CoV-2 Spike S1 protein-coupled magnetic beads
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Launched
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S protein RBD
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MBS-K002
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SARS-CoV-2 Spike protein RBD-coupled magnetic beads
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Launched
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S1 protein
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SP-12
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SARS-CoV-2 Spike S1 protein-Coated Plates, Clear, 96-Well
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Launched
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S protein RBD
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RP-13
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SARS-CoV-2 Spike protein RBD-Coated Plates, Clear, 96-Well
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Launched
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Relevant proteins
ACRO supplies several SARS-CoV-2 antigen proteins and their mutants to help the research on the binding and inhibition performance of the antibodies.
Relevant products:
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Molecule
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Cat.No.
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Product description
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Status
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S1 protein
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S1N-C82E8
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Biotinylated SARS-CoV-2 (COVID-19) S1 protein, His,Avitag™ (MALS verified)
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Launched
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S1 protein
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S1N-C52H3
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SARS-CoV-2 (COVID-19) S1 protein, His Tag
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Launched
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S1 protein
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S1N-C5256
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SARS-CoV-2 (COVID-19) S1 protein (D614G), His Tag
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Launched
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S protein RBD
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SPD-C82E9
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Biotinylated SARS-CoV-2 (COVID-19) S protein RBD, His,Avitag™ (MALS verified)
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Launched
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S protein RBD
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SPD-C5255
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SARS-CoV-2 (COVID-19) S protein RBD, Fc Tag (MALS verified)
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Launched
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S protein RBD
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*SPD-S52H4
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SARS-CoV-2 (COVID-19) S protein RBD (V367F), His Tag
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Launched
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S protein RBD
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*SPD-S52H5
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SARS-CoV-2 (COVID-19) S protein RBD (N354D), His Tag
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Launched
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S protein RBD
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*SPD-S52H7
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SARS-CoV-2 (COVID-19) S protein RBD (W436R), His Tag
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Launched
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S protein RBD
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*SPD-S52H8
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SARS-CoV-2 (COVID-19) S protein RBD (R408I), His Tag
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Launched
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S protein RBD
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*SPD-S52H3
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SARS-CoV-2 (COVID-19) S protein RBD (N354D/ D364Y), His Tag
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Launched
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S protein RBD
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SPD-C52H4
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SARS-CoV-2 (COVID-19) S protein RBD (G476S), His Tag
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Coming soon
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S protein RBD
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SPD-C52H5
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SARS-CoV-2 (COVID-19) S protein RBD (V483A), His Tag
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Coming soon
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※Note: products whose category numbers with * labeled were employed in this research.
References:
- Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody libraries
- http://life.acrobiosystems.cn/e/535472/s-qnQ5mAHyiY-HZaNfdW9o3Q/2fvmggp/935800212?h=mj4TUkj1is44ksKnnZ0JVaxoNeB6Ov2z59rSGinzoEI
More SARS-CoV-2 related products:
>>> All SARS-CoV-2 related products
>>> SARS-CoV-2 related kit products
>>> Proteins for COVID-19 Serological Test Development
>>> Pre-coupled protein magnetic beads
※ Any custom requests, suggestions or feedback are welcome. Click here >>
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