40+ Fc receptors with multiple species and tags verified by SPR/BLI/ELISA
The efficacy of a therapeutic antibody not only depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors. The binding affinity of the Fc fragment towards FcRn (FCGRT&B2M) would predict the antibody’s half-life, while that between the Fc fragment and FcγRIIIa (CD16a) would influence the antibody’s ability to elicit ADCC (antibody dependent cell mediated cytotoxicity). Therefore, candidates must be tested against a panel of receptors during antibody engineering.
ACROBiosystems offers 47 Fc receptors with different molecules, species, tags and biotin conjunction to help expedite your mAb development.
※High purity，bioactivity and batch-to-batch consistency
※HPLC/SPR/BLI verified and protocol offered for free
Fig. 2 Human CD64, His Tag (SPR & BLI verified) (Cat. No. FCA-H52H1) captured on CM5 chip via anti-His antibody can bind Herceptin with an affinity constant of 4.92 nM as determined in a SPR assay (Biacore 8K)