ACROBiosystems | 用於 ADC Linker 篩選和驗證的蛋白酶 (Proteases)

ACROBiosystems | 用於 ADC Linker 篩選和驗證的蛋白酶 (Proteases)

2025.02.20

 

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In the development of antibody-drug conjugates (ADCs), the linker plays a crucial role by connecting the antibody and cytotoxic payload, influencing key properties such as stability, potency, safety, and pharmacokinetics (PK). Selecting the appropriate linker is paramount for maximizing the therapeutic efficacy and safety of ADCs.

 

Explore our ADC proteases for peptide linkers to power your screening and validation of ADC linkers!

Our feature product encompassing:

·    Cathepsin B, Cathepsin L, Cathepsin S

·    MMP-2, MMP-7, MMP-9 

·    β-glucuronidase, β-galactosidase

 

Product Features

 

·    Natural conformation: HEK293 expressed protein to ensure the natural structure

·    Robust and consistent enzyme activity, ensuring reproducibility across batches

·    High purity: Verified by SDS-PAGE and SEC-MALS

Case Show

Case studies show that ADC DS-8201 can be cleaved by Cathepsin B from ACROBiosystems

 

 

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Awards & Certifications

 

 

ACROBiosystems | 1 Innovation Way | Newark, DE 19711 US

 

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