本文轉載自原廠電子報:ACROBiosystems | www.acrobiosystems.com
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Fc receptor: the potential target proteins
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Fc receptors play a key role in immune cell activation through antibody stimulation, they can specifically bind to the Fc region of the immunoglobulins. In addition, FcR has become a key participant in the pathogenesis of several important autoimmune diseases. Targeting Fc receptors as a therapeutic method for the treatment of inflammatory diseases and cancers. For example, blocking/neutralizing activated receptors (Antibody), Inhibitory FcγRIIB
(agonist) participation. Therefore, high-quality Fc receptors are indispensable.
ACROBiosystems
has launched the FcR proteins with the SUMO fusion tag and HAS fusion tag, which can be used in immunization and antibody screening to accelerating the development of specific antibody drugs.
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Human Fc gamma RIIIA / CD16a (V176) Protein, SUMO,His Tag
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Human Fc gamma RIIIA / CD16a (V176) Protein, SUMO,His Tag
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Human Fc gamma RIIB / CD32b Protein, SUMO,His Tag
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Human Fc gamma RIIB / CD32b Protein, HSA,His Tag
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Biotinylated Human CD32a (H167), Avitag,His Tag (SPR & BLI verified) (Cat. No. CDA-H82E6
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captured on Biotin CAP- Series S Sensor Chip can bind Rituximab with an affinity constant of 0.66 μM as determined in a SPR assay (Biacore T200).
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Loaded Human Fc gamma RIIB / CD32b Protein, HSA,His Tag (MALS verified) (Cat. No. CDB-H52S9
) on HIS1K Biosensor, can bind Rituximab with an affinity constant of 2.9 μM as determined in BLI assay (ForteBio Octet Red96e)
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With a strong team of scientists, ACROBiosystems also provides high-quality integrated SPR&BLI analytical services. ACRO has served and collaborated with more than 100 customers from academia and industry. Our work supported multiple antibody drugs IND applications.
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