antibodies-online | 新冠病毒(SARS-CoV-2)宿主之間的相互作用

antibodies-online | 新冠病毒(SARS-CoV-2)宿主之間的相互作用

2020.06.16

 

【antibodies-online|新冠病毒(SARS-CoV-2)宿主之間的相互作用】

SAV-CoV-2(COVID-19的致病因子)的基因組總共編碼29種蛋白質:16種非結構蛋白(Nsp1-16),4種結構蛋白(S,E,M,N)和9種輔助因子(Orf3a,Orf3b,Orf6,Orf7a,Orf7b,Orf8,Orf9b,Orf9c,Orf10)。這些蛋白質決定病毒複製和病毒粒子的產生。此外,它們與人類宿主的相互作用對於調節免疫反應、COVID-19的發育和進程至關重要。

 

 

SARS-CoV-2: Studying Virus Host Interactions

 

The genome of SARS-CoV-2, the causative agent of COVID-19, encodes a total of 29 proteins: 16 non-structural proteins (Nsp1-16), 4 structural proteins (S, E, M, N), and 9 accesscory factors (Orf3a, Orf3b, Orf6, Orf7a, Orf7b, Orf8, Orf9b, Orf9c, Orf10). These proteins determine virus replication and the production of virions. In addition, their interaction with the human host are essential to modulate the immune response and thus development and course of COVID-19. 

 

The SARS-CoV-2 Interactome outlines numerous potential interactions of SARS-CoV-2 with host cell proteins1. Each of these interactions holds potentially the key to stop SARS-CoV-2 in its tracks. Many of the interaction partners can be targeted by existing drugs. It is now the time for a detailed understanding of the way how SARS-CoV-2 interacts with its host. 

 

SARS-CoV-2 human host cell interactome

 

antibodies-online offers a comprehensive collection of antibodies and proteins to study and verify these actions. Among these products are the neutralizing anti-S-protein antibody clone CR3022, the recombinant anti-N-protein antibody ABIN6952664, and the non-structural proteins. 

 

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