The genome of SARS-CoV-2, the causative agent of COVID-19, encodes a total of 29 proteins: 16 non-structural proteins (Nsp1-16), 4 structural proteins (S, E, M, N), and 9 accesscory factors (Orf3a, Orf3b, Orf6, Orf7a, Orf7b, Orf8, Orf9b, Orf9c, Orf10). These proteins determine virus replication and the production of virions. In addition, their interaction with the human host are essential to modulate the immune response and thus development and course of COVID-19.
The SARS-CoV-2 Interactome outlines numerous potential interactions of SARS-CoV-2 with host cell proteins1. Each of these interactions holds potentially the key to stop SARS-CoV-2 in its tracks. Many of the interaction partners can be targeted by existing drugs. It is now the time for a detailed understanding of the way how SARS-CoV-2 interacts with its host.
antibodies-online offers a comprehensive collection of antibodies and proteins to study and verify these actions. Among these products are the neutralizing anti-S-protein antibody clone CR3022, the recombinant anti-N-protein antibody ABIN6952664, and the non-structural proteins.