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Exosomes are small extracellular microvesicles (EMV) that can contain a vast array of proteins depending on the cell from which they originate.
It has been suggested that SARS-CoV-2 may exploit the exosome transport based on studies showing that SARS-CoV is released from infected cell by exocyotosis. SARS-CoV-2 Nsp3, Nsp4, and Nsp6 also induce the formation of double-membrane vesicles (DMVs), suggesting a connection a role of exosomes in virus propagation. This might also enable the virus to evade immune detection and explain apparent reinfection of convalescent COVID-19 patients. To find out more about exosomes, exosomal markers, and related products visit our resource covering this topic. |
Featured Exosome Marker Antibodies
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In case you have any further questions please don’t hesitate to get in touch with me. Best regards, Stefan Pellenz, Ph.D. |
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References: Qian, Z. et al. Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus. Am. J. Respir. Cell Mol. Biol. 48, 742–8 (2013). Elrashdy, F. et al. On the potential role of exosomes in the COVID-19 reinfection/reactivation opportunity. J. Biomol. Struct. Dyn. 1–12 (2020). doi:10.1080/07391102.2020.1790426 Farkash, E. A. et al. Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2. J. Am. Soc. Nephrol. 31, 1683–1687 (2020). |
