antibodies-online |COVID-19疫苗:更適合於免疫原性評估的新穗蛋白變體

antibodies-online |COVID-19疫苗:更適合於免疫原性評估的新穗蛋白變體


The SARS-CoV-2 Spike Protein is essential in the attack on human cells and is therefore an important target in the development of therapeutics and vaccines.

In the development of most COVID-19 vaccines, the Spike Protein was used to trigger the immune response. The structural change by the replacement of two proline amino acids in the S2 subunit of the Spike Protein (S-2P), stabilizes the trimer and keeps the protein longer in prefusion state, which leads to a stronger immune response.

Recent research results indicate that four additional proline mutations in the S2 subunit (S-6P) stabilize the structure of the trimer even more and keeps most of the protein in prefusion state. That means, S-6P shows superior bioactivity over S-2P.  

S-6P shows the best result when comparing the signal-to-noise ratios of four different Spike Trimer Proteins using ten different patient samples. In conclusion: S-6P is the best recombinant protein for the vaccine immunogenicity evaluation.

antibodies-online offers a series of S-6P proteins

Super Stable Trimer proteins

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SARS-CoV-2 S1 protein (His tag)


SARS-CoV-2 S1 (D614G) protein (His tag)


Biotinylated SARS-CoV-2 S1 (D614G) protein (His-Avi Tag)


Biotinylated SARS-CoV-2 S1 protein (His-Avi Tag)



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