Neurotrophins are a family of secreted proteins that are critical for the development and maintenance of the nervous system.
Their primary role during development is to regulate neuronal populations by promoting the survival of neurons that form appropriate connections and inducing programmed cell death (apoptosis) in those that do not..
The classical neurotrophin family consists of structurally related proteins that signal through the Tropomyosin receptor kinase (Trk)
family of receptor tyrosine kinases.
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