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Mature BDNF quantification in human blood has been of intense focus over the last decade, with increasing number of studies investigating the role of mature BDNF in diverse research fields such as excercise metabolism and drug use. For instance, Miyamoto
et al. (2021) found that serum BDNF levels are increased in high-cadence aerobic excercise. In another study, Holze et al. (2020) found significantly increased plasma BDNF levels after administration of high LSD doses.
Research into proBDNF physiology has lagged behind, with studies aiming at identifying the source of blood proBDNF. In their recent publication, Le Blanc
et al. (2020) reported that human platelets contain proBDNF, but in contrast to mature BDNF, is not released upon platelet activation, adding further complexity to the mature BDNF/proBDNF relationship.