Creative Bioarray |體內和體外滲透性模型-提供體內吸收的準確預測

Creative Bioarray |體內和體外滲透性模型-提供體內吸收的準確預測


本文轉載自原廠電子報: Creative Bioarray |

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In Vitro and Ex Vivo
Permeability Study

Assess compound permeability to provide accurate
predictions of in vivo absorption
Of many important features of drug candidates, permeability is an essential parameter to influence
the absorption and distribution of a drug. To test permeability, the use of in vivo or in situ animal
models raises unavoidable ethical concerns and presents a difficulty when a high-throughput screening
test is needed. Therefore, in vitro studies have been increasingly expected to evaluate drug permeability.
Creative Bioarray provides in vitro permeability assay services to determine intestinal, blood-brain
barrier (BBB) penetration or vascular permeability. Our experts are experienced working with permeability
models. We ensure consistent and high-quality data with a fast turnaround time.
In vitro intestinal permeability models
Creative Bioarray provides a set of monolayer
barrier permeability systems that can be time saving and cost-effective for your oral absorption,
bioavailability evaluation, drug transporter, and drug-drug interaction studies.
Bioarray-20201013-InVitro-03 Caco-2 epithelial monolayer barrier
Bioarray-20201013-InVitro-03 P-gp overexpressed Caco-2 epithelial monolayer barrier
Bioarray-20201013-InVitro-03 Transporter silenced Caco-2 (BCRP, MDR1) epithelial monolayer barrier
Bioarray-20201013-InVitro-03 Intestinal epithelial tight junction barrier (T84, HT29, Caco-2, and HCT116)
Bioarray-20201013-InVitro-03 Mucus-producing intestinal epithelial monolayer barrier (HT29- MTX)
Bioarray-20201013-InVitro-03 MDCK/MDR1 monolayer barrier
Ex vitro intestinal permeability models
Creative Bioarray offers an ex vivo permeability
assay using intestinal sacs to measure overall intestinal integrity and comparative transport of
a specific molecule. The intestinal sacs will provide a way to calculate the apparent permeability
of a molecule across the intestinal barrier or to examine regional epithelial barrier dysfunction
using fluorescent-labeled dextrans.
In vitro blood-brain barrier permeability models
To expedite brain research and the R&D of novel
drugs for various neurological diseases, we have established different in vitro BBB models. Our
novel models use only primary human cells and include four key BBB cells: astrocytes, pericytes,
brain microvascular endothelial cells (BMECs), and neurons.
Bioarray-20201013-InVitro-03 Monolayer BBB models (BMECs)
Bioarray-20201013-InVitro-03 Co-culture BBB models (BMECs–pericytes–astrocytes)
Bioarray-20201013-InVitro-03 Microfluidic models
With decades of operational experience, Creative Bioarray can provide the
following analytical services based on our permeability models:
Bioarray-20201013-InVitro-04 Prioritize candidates for the possibility of adverse effects
Bioarray-20201013-InVitro-04 Predict various permeability processes (paracellular, transcellular)
Bioarray-20201013-InVitro-04 Estimate different intracellular concentrations (membrane, cytosol, lysosome)
Bioarray-20201013-InVitro-04 Assess the impact of experimental variability on the predicted outcomes
Bioarray-20201013-InVitro-04 Analysis of measured in vitro permeability data


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