Assess compound permeability to provide accurate
predictions of in vivo absorption
Of many important features of drug candidates, permeability is an essential parameter to influence
the absorption and distribution of a drug. To test permeability, the use of in vivo or in situ animal
models raises unavoidable ethical concerns and presents a difficulty when a high-throughput screening
test is needed. Therefore, in vitro studies have been increasingly expected to evaluate drug permeability.
Creative Bioarray provides in vitro permeability assay services to determine intestinal, blood-brain
barrier (BBB) penetration or vascular permeability. Our experts are experienced working with permeability
models. We ensure consistent and high-quality data with a fast turnaround time.
In vitro intestinal permeability models
Creative Bioarray provides a set of monolayer
barrier permeability systems that can be time saving and cost-effective for your oral absorption,
bioavailability evaluation, drug transporter, and drug-drug interaction studies.
Creative Bioarray offers an ex vivo permeability
assay using intestinal sacs to measure overall intestinal integrity and comparative transport of
a specific molecule. The intestinal sacs will provide a way to calculate the apparent permeability
of a molecule across the intestinal barrier or to examine regional epithelial barrier dysfunction
using fluorescent-labeled dextrans.
In vitro blood-brain barrier permeability models
To expedite brain research and the R&D of novel
drugs for various neurological diseases, we have established different in vitro BBB models. Our
novel models use only primary human cells and include four key BBB cells: astrocytes, pericytes,
brain microvascular endothelial cells (BMECs), and neurons.