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Interleukin-12 (IL-12) is a naturally produced cytokine by dendritic cells, macrophages, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 plays a pivotal role in immune regulation by enhancing the activity of natural killer (NK) cells and T cells, inducing IFN-γ production, and promoting Th1 immune responses. Through the JAK-STAT signaling pathway, IL-12 triggers cytokine secretion and cytotoxic responses, making it a key target in immunotherapy and cancer research.
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Product Highlights
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Creative BioMart offers a wide range of high-quality IL-12-related products to meet a diverse range of research and production needs:
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Recombinant Proteins
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Product Name
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Source Host
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Species
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Tag
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Features
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IL12-001H
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CHO
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Human
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Fc-tagged
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High activity, ideal for immune regulation studies
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IL12-12H
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HEK293
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Human
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His-tagged
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Cost-effective, suitable for basic research
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IL12-4327H
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CHO
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Human
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Non
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Heterodimeric protein, ensures functional integrity
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GMP-Grade Products
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IL12-158HG: GMP-grade recombinant human IL-12 proteins are available in 50μg, 500μg, and 1mg sizes.
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IL12-01H: GMP-grade recombinant human IL-12 proteins are available CHO-derived and untagged, ensuring high purity and bioactivity.
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Diverse Options
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Multiple Host Sources: Select from CHO, HEK293, insect cells, etc., to meet your specific experimental needs.
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Flexible Tag Options: Choose from His, Fc, Flag, Strep, etc., for downstream applications.
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Various Sizes: We cater to both small-scale experiments and large-scale production.
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Applications
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Immunotherapy: Enhances NK cell and T cell activity to promote anti-tumor immune responses.
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Vaccine Development: Acts as an adjuvant to enhance immune responses.
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Basic Research: Explore the role of IL-12 in immune regulation and signal transduction.
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Cell Culture: IL-12 is crucial for in vitro expansion and activation of NK cells. Creative BioMart’s GMP-grade IL-12 and IL-18 proteins have demonstrated excellent performance in promoting NK cell expansion with high viability, providing a reliable solution for the development of NK cell-based therapies.
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Why Choose Creative BioMart?
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Quality Assurance: All products are strictly quality-controlled to ensure high activity and batch-to-batch consistency.
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SDS-PAGE Test
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Activity Test
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Comprehensive Product Line: We offer a full range of IL-12 and related proteins (e.g., IL-12B, IL-12A, IL-18).
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Professional Technical Support: Our experts provide comprehensive support from product selection to experimental design.
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Visit our website or contact our sales team to get more information and customized solutions. Accelerate your research and drive innovation in immunotherapy with Creative BioMart’s IL-12 products!
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USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-559-9269 / 1-516-512-3133
Fax: 1-631-938-8127 Germany 65830 Kriftel, Gutenbergstraße 5. Frankfurt am Main, Germany
+491793975992
Email: info@creative-biomart.org
Global Locations CREATIVE BIOMART INC.
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