Creative Diagnostics | 突變株SARS-CoV-2 BA.2.75 VSV偽病毒即將販售

Creative Diagnostics | 突變株SARS-CoV-2 BA.2.75 VSV偽病毒即將販售

2022.08.22

 

突變株SARS-CoV-2 BA.2.75  VSV偽病毒即將販售

Creative Diagnostics 推出了全系列Wild type以及最新omicron 突變株的VSV 偽病毒,以研究 SARS-CoV-2 棘蛋白與人類 ACE2 在生理相關背景下的相互作用。
VSV的SARS-CoV-2 偽病毒與慢病毒型的偽病毒相比, VSV 的 SARS-CoV-2 偽病毒具有相對較高的偽病毒效價,其RLU值可以高達108,是慢病毒系統的100倍,使得檢測的信噪比更高,精度和重複性更好。此外VSV偽病毒可以用於容易獲得的細胞株如 Huh-7 或 Vero。

SARS-CoV-2 WT rVSV-ΔG Pseudovirus

Cat. No.

Product Name

Reporter Gene

Envelope Glycoproteins

COV-PSV10

Pseudotyped VSV-SARS-CoV-2 S-ΔG-mCherry

mCherry

SARS-CoV-2 Spike (Wuhan-Hu-1)

COV-PSV11

Pseudotyped VSV-SARS-CoV-2 S-ΔG-EGFP

GFP

SARS-CoV-2 Spike (Wuhan-Hu-1)

COV-PSV12

Pseudotyped VSV-SARS-CoV-2 S-ΔG-Luciferase

Luciferase

SARS-CoV-2 Spike (Wuhan-Hu-1)

SARS-CoV-2 Variant rVSV-ΔG Pseudovirus

Cat. No.

SARS-CoV-2 / Variant

SARS-CoV-2 / Variant

Mutations

COV-PSV30

Omicron variant, BA.2.75

Omicron

T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P

COV-PSV26

Omicron variant, BA.1.1

Omicron

A67V, Δ69-70, T95I, G142D, Δ143-145, Δ211, L212I, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F

COV-PSV27

Omicron variant, BA.2.12.1

Omicron

T19I, L24S, Δ25-27, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K

COV-PSV28

Omicron variant, BA.3

Omicron

A67V, Δ69-70, T95I, G142D, Δ143-145, N211I, Δ212, G339D, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K

COV-PSV29

Omicron variant, BA.4/BA.5

Omicron

T19I, LPPA24S, HV69del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K

COV-PSV25

Omicron variant, BA.2

Omicron

T19I, L24S, del25-27, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K

COV-PSV24

Omicron variant, B.1.1.529

Omicron

A67V, Δ69-70, T95I, G142D/Δ143-145, Δ211/L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F

COV-PSV13

D614G

———

D614G

COV-PSV14

Indian variant B.1.617.1

Kappa

G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H

COV-PSV15

Indian variant B.1.617.2

Delta

T19R, G142D, del156/157, R158G, L452R, T478K, D614G, P681R, D950N

COV-PSV16

C.37

Lambda

G75V, T76I, R246N, del247-253, L452Q, F490S, D614G, T859N

COV-PSV17

Brazilian variant P.1, 20J/501Y.V3

Gamma

ΔH69/V70, ΔY144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H

COV-PSV18

South African variant Δ3 B.1.351, 20H/501Y.V2

Beta

L18F, D80A, D215G, ΔL242/A243/L244, R246I, K417N, N501Y, E484K, D614G, A701V

COV-PSV19

UK variant B.1.1.7, 20I/501Y.V1

Alpha

ΔH69/V70, ΔY144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H

產品特色

可提供來自多種冠狀病毒物種的Wild type型或突變型棘蛋白
• 
在 BSL-2 實驗室中使用安全
• 
無限制的客製化選項,例如加入reporter gene以檢測病毒是否成功進入細胞
• 
嚴謹的品管品質
• 
可用於 Huh-7 或 Vero 等容易取得的細胞株
更好的精確性和可重複性

 

 

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