Creative Diagnostics | 簡化基因治療患者篩選Anti-AAV Antibody ELISA Kits

Creative Diagnostics | 簡化基因治療患者篩選Anti-AAV Antibody ELISA Kits

2023.05.05

 

Anti-AAV Antibody ELISA Kits

快速篩選接受基因治療患者是否本身存在Anti-AAV Antibody

Adeno-associated viruses (AAV) 是使用最廣泛的基因傳遞載體之一,在全球越來越多的 FDA 申請和臨床試驗中使用AAV。 然而由於 AAV 的病毒capsids會誘導細胞和體液產生免疫反應,引發載體與抗 AAV 抗體的中和作用,進而阻止病毒感染。 此外超過 90% 的人本身存在一些 AAV 的結合抗體。 其中一些抗體具有中和作用,甚至在第一次給藥時也可能導致療效喪失。 因此需要提高對 AAV 免疫性風險的理解,並開發評估和減輕中和反應的技術。

 

Creative Diagnostics 針對最常用的 AAV 血清型開發了一系列抗 AAV 抗體 ELISA 試劑盒。 為篩選 AAV 血清陽性而開發的標準化檢測已被證明是篩選患者預先存在的抗體,進而降低安全問題,此kit是 AAV 基因治療時不可少的工具。

產品特點

高靈敏檢測針對AAV capsids的免疫反應

測量數值可再現

定性或半定量

不同批次一致性

比細胞檢測原理更快更容易
  產品資訊

Cat. No.

Product Name

Application

DEIASL345

Human Anti-AAV8 Antibody ELISA Kit

Qualitative ELISA

DEIASL345M

Mouse Anti-AAV8 Antibody ELISA Kit

Qualitative ELISA

DEIASL348

Human Anti-AAV9 Antibody ELISA Kit

Qualitative ELISA

DEIASL348M

Mouse Anti-AAV9 Antibody ELISA Kit

Qualitative ELISA

DEIASL347

Human Anti-AAV2 Antibody ELISA Kit

Qualitative ELISA

DEIASL344*

Human Anti-AAV6 Antibody ELISA Kit

Qualitative ELISA

DEIASL343*

Human Anti-AAV5 Antibody ELISA Kit

Qualitative ELISA

* Coming soon

其他資訊

 

AAV For Gene Therapy

 

Today, recombinant adeno-associated virus (rAAV) has become the main platform for in vivo gene therapy delivery. The first rAAV gene therapy product, Alipogene Tiparvovec (Glybera) from uniQure, was approved by the European Medicines Agency (EMA) in 2012 for the treatment of lipoprotein lipase deficiency.

 

更多資訊

 

 

 

AAV Antibodies and Titration ELISA

 

Adeno-Associated Virus (AAV) is a nonpathogenic virus that is widely used as a vector in gene therapy. Creative Diagnostics currently provides a full range of adeno-associated virus (AAV) antibodies that specifically recognize intact virus capsids as well as antibodies specific to AA-viral subunits and replicases.

 

更多資訊

 

 

 

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