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Mutant SARS-CoV-2 Pseudotyped Lentiviruses

SARS-CoV-2 pseudotyped lentivirus is replication-incompetent with safe (BSL-2), easy, and high-throughput viral infectivity and can be used in neutralization assays with standard detection instrumentation. It displays an antigenically correct spike protein on a heterologous virus core and carries a modified genome that expresses a convenient optical reporter gene (GFP or luciferase).

Creative Diagnostics has launched a full range of ready-to-use wild-type and newly emerged mutant SARS-CoV-2 pseudotyped lentiviruses to study the interaction between SARS-CoV-2 spike protein and human ACE2 in a physiologically relevant context.

Variants of Concern—AVAILABLE NOW

Cat. No.	Product Name
COVL-B117	Pseudotyped Luciferase rSARS-CoV-2 Spike (UK Variant B.1.1.7)
COVG-B117	Pseudotyped GFP rSARS-CoV-2 Spike (UK Variant B.1.1.7)
COVL-JBV1	Pseudotyped Luciferase rSARS-CoV-2 Spike, Japanese/Brazilian Variant (P.1)
COVG-JBV1	Pseudotyped GFP rSARS-CoV-2 Spike, Japanese/Brazilian Variant (P.1)
COVL-501YV2	Pseudotyped Luciferase rSARS-CoV-2 Spike (South African Variant 501Y.V2)
COVG-501YV2	Pseudotyped GFP rSARS-CoV-2 Spike (South African Variant 501Y.V2)
COVL-B1617	Pseudotyped Luciferase rSARS-CoV-2 Spike, B.1.617 India
COVG-B1617	Pseudotyped GFP rSARS-CoV-2 Spike, B.1.617 India
COVL-452R	Pseudotyped Luciferase rSARS-CoV-2 Spike, Californian L452R Variant (B.1.427/B.1.429)
COVG-452R	Pseudotyped GFP rSARS-CoV-2 Spike, Californian L452R Variant (B.1.427/B.1.429)

Click HERE for a Full List

Features

●	Pseudotyping available with the wild type or mutant spike proteins from a wide range of coronavirus species
●	Safe to be used in BSL-2 labs
●	Unlimited customization options including the addition of reporter genes for monitoring viral entry
●	Quality-controlled production for use as a critical reagent

Resources

SARS-CoV-2 Spike Stable Cell Line

The SARS-CoV-2 spike CHO-K1 cell line has been developed by the stable transfection of the SARS-CoV-2 spike protein plasmid. SARS-CoV-2 spike CHO-K1 cell line provides consistent levels of expression of the SARS-CoV-2 spike protein on the cell surface.

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SARS-CoV-2 Neutralizing Antibody ELISA Kit

With the demand for vaccine development, Creative Diagnostics has developed two ELISA kits for the qualitative detection of SARS-CoV-2 neutralizing antibodies in serum and plasma. Our competitive assay format measures neutralizing antibodies of the SARS-CoV-2 spike RBD and ACE2 interaction in human plasma and serum.

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Coronavirus Research

Coronaviruses are a family of enveloped RNA viruses that infect various mammals as well as birds. Of clinical importance is the Human coronaviruses (HCoVs), which belong to the coronaviridae family. HCoVs have been identified to be a frequent cause of respiratory tract infections, causing mild to severe respiratory diseases.

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Creative Diagnostics 突變型SARS-CoV-2 假型慢病毒

Creative Diagnostics 突變型SARS-CoV-2 假型慢病毒

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