CUSABIO | 抗體藥物複合體(ADC)熱門研究標-HER2, MS4A1, TACSTD2, FOLR1, MSLN, CLDN18

CUSABIO | 抗體藥物複合體(ADC)熱門研究標-HER2, MS4A1, TACSTD2, FOLR1, MSLN, CLDN18

2022.10.14

到目前為止,抗體藥物複合體(ADC)可以說是有很大的進展,尤其是在實體瘤或血液腫瘤的治療方面。ADC 的原理是將抗體和細胞毒性分子結合,可以提高化療的有效性並降低其毒性。有鑑於一些已獲批准的 ADC 藥物的成功案例,許多研究人員和製藥公司特別關注 ADC 的有效標的。以目前來說 HER2 是 ADC 藥物設計最有利的靶點,其次是許多 CD 分子和其他熱門的靶點,如 FOLR1、MSLN、CLDN18。此外 研究ADC 更有潛力的標的有增長的趨勢。(閱讀更多 ADC 相關文章)

 

對於ADC或藥物開發的研究和製藥公司,CUSABIO能提供一系列ADC高效靶點產品,包括最熱門的標的HER2, MS4A1, TACSTD2, FOLR1, MSLN, CLDN18, TF, NECTIN4, ALCAM; 熱門的CD分子 CD19, CD22, CD276, CD33, CD37 等,協助進行ADC研究或ADC新藥研究。 (詳見下表)

 

各樣實驗驗證

高純度-SDS-PAGE驗證

The purity of human CD22 (Cat. No. CSB-MP004900HU) was more than 94% verified by SDS-PAGE.

The purity of human CD276 (Cat. No. CSB-MP733578HU) was more than 93% verified by SDS-PAGE.

The purity of human CD33 (Cat. No. CSB-MP004925HU) was more than 95% verified by SDS-PAGE.

The purity of human CD46 (Cat. No. CSB-MP004939HU) was more than 92% verified by SDS-PAGE.

● 序列準確-LC-MS/MS驗證

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of Human CA9 (Cat. No. CSB-EP614990HUc0) could indicate that this peptide derived from E.coli-expressed Human CA9.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of Human CASP3 (Cat. No. CSB-EP004548HU) could indicate that this peptide derived from E.coli-expressed Human CASP3.

● 高生物活性-ELISA驗證

Immobilized human CD48 (Cat. No. CSB-MP004941HU) at 2 μg/mL can bind Anti-CD48 rabbit monoclonal antibody, the EC50 of human CD48 protein is 0.5806-0.8463 ng/mL.

Immobilized human DLL3 (Cat. No. CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody (CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.

Immobilized human ERBB2 (Cat. No. CSB-MP007763HU) at 2 μg/mL can bind Trastuzumab, the EC50 is 2.179-2.825 ng/mL.

Immobilized human MET (Cat. No. CSB-MP013714HU) at 2 μg/mL can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094 ng/mL.

● 高親和性-LSPR驗證

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (Cat. No. CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (Cat. No. CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

 ADC熱門產品

Target

Product Name

Code

Source

Tag Info

CD22

Recombinant Human B-cell receptor CD22(CD22),partial (Active)

CSB-MP004900HU

Mammalian cell

C-terminal 6xHis-tagged

CD276

Recombinant Human CD276 antigen(CD276),partial (Active)

CSB-MP733578HU

Mammalian cell

C-terminal hFc-Myc-tagged

CD33

Recombinant Human Myeloid cell surface antigen CD33(CD33),partial (Active)

CSB-MP004925HU

Mammalian cell

C-terminal hFc-Myc-tagged

CD46

Recombinant Human Membrane cofactor protein(CD46) (Active)

CSB-MP004939HU

Mammalian cell

C-terminal hFc-tagged

CLDN18

Recombinant Human Claudin-18.2(CLDN18.2)-VLPs (Active)

CSB-MP005498HU(A5)

Mammalian cell

C-terminal 10xHis-tagged

DLL3

Recombinant Human Delta-like protein 3(DLL3),partial (Active)

CSB-MP882142HU

Mammalian cell

C-terminal 6xHis-tagged

DLL3

Recombinant Macaca fascicularis Delta-like protein 3(DLL3),partial (Active)

CSB-MP3536MOV

Mammalian cell

C-terminal 6xHis-tagged

EGFR

Recombinant Human Epidermal growth factor receptor(EGFR),partial (Active)

CSB-MP007479HU

Mammalian cell

N-terminal 10xHis-tagged and C-terminal Myc-tagged

ERBB2

Recombinant Human Receptor tyrosine-protein kinase erbB-2(ERBB2),partial (Active)

CSB-MP007763HU

Mammalian cell

C-terminal 6xHis-tagged

ERBB3

Recombinant Human Receptor tyrosine-protein kinase erbB-3(ERBB3),partial (Active)

CSB-MP007765HU

Mammalian cell

C-terminal hFc-tagged

MET

Recombinant Human Hepatocyte growth factor receptor(MET),partial (Active)

CSB-MP013714HU

Mammalian cell

C-terminal hFc-tagged

MS4A1

Recombinant Human B-lymphocyte antigen CD20(MS4A1)-VLPs (Active)

CSB-MP015007HU

Mammalian cell

C-terminal 10xHis-tagged

MSLN

Recombinant Human Mesothelin(MSLN),partial (Active)

CSB-MP015044HUc9

Mammalian cell

N-terminal hFc-tagged

NECTIN4

Recombinant Human Nectin-4(NECTIN4),partial (Active)

CSB-MP822274HU

Mammalian cell

C-terminal 10xHis-tagged

ROR1

Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1(ROR1),partial (Active)

CSB-MP020067HU1d7

Mammalian cell

C-terminal 10xHis-tagged

TACSTD2

Recombinant Human Tumor-associated calcium signal transducer 2(TACSTD2),partial (Active)

CSB-MP023072HU1

Mammalian cell

C-terminal hFc-tagged

TNF

Recombinant Human Tumor necrosis factor(TNF),partial (Active)

CSB-EP023955HUc7

E.coli

C-terminal 6xHis-tagged

TNFRSF10B

Recombinant Human Tumor necrosis factor receptor superfamily member 10B(TNFRSF10B),Partial (Active)

CSB-AP002291HU

E.coli

Tag-Free

TNFRSF17

Recombinant Human Tumor necrosis factor receptor superfamily member 17(TNFRSF17),partial (Active)

CSB-MP023974HU1

Mammalian cell

C-terminal hFc-tagged

TNFSF8

Recombinant Human Tumor necrosis factor ligand superfamily member 8(TNFSF8),partial (Active)

CSB-MP023996HU1

Mammalian cell

N-terminal 6xHis-tagged

TNFSF8

Recombinant Human Tumor necrosis factor ligand superfamily member 8(TNFSF8),partial (Active)

CSB-MP023996HU1c9

Mammalian cell

N-terminal hFc-tagged

更多ADC標的

 

back-Top
open-line

LINE 線上諮詢

亞旭-LINE-QRcode

掃瞄或手機直接點擊條碼

error: Content is protected !!