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到目前為止,抗體藥物複合體(ADC)可以說是有很大的進展,尤其是在實體瘤或血液腫瘤的治療方面。ADC 的原理是將抗體和細胞毒性分子結合,可以提高化療的有效性並降低其毒性。有鑑於一些已獲批准的 ADC 藥物的成功案例,許多研究人員和製藥公司特別關注 ADC 的有效標的。以目前來說 HER2 是 ADC 藥物設計最有利的靶點,其次是許多 CD 分子和其他熱門的靶點,如 FOLR1、MSLN、CLDN18。此外 研究ADC 更有潛力的標的有增長的趨勢。(閱讀更多 ADC 相關文章)
對於ADC或藥物開發的研究和製藥公司,CUSABIO能提供一系列ADC高效靶點產品,包括最熱門的標的HER2, MS4A1, TACSTD2, FOLR1, MSLN, CLDN18, TF, NECTIN4, ALCAM; 熱門的CD分子 CD19, CD22, CD276, CD33, CD37 等,協助進行ADC研究或ADC新藥研究。 (詳見下表) |
各樣實驗驗證
● 高純度-SDS-PAGE驗證
● 序列準確-LC-MS/MS驗證
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of Human CA9 (Cat. No. CSB-EP614990HUc0) could indicate that this peptide derived from E.coli-expressed Human CA9.
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Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of Human CASP3 (Cat. No. CSB-EP004548HU) could indicate that this peptide derived from E.coli-expressed Human CASP3.
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● 高生物活性-ELISA驗證
● 高親和性-LSPR驗證
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ADC熱門產品
Target
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Product Name
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Code
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Source
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Tag Info
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CD22
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Recombinant Human B-cell receptor CD22(CD22),partial (Active)
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CSB-MP004900HU
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Mammalian cell
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C-terminal 6xHis-tagged
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CD276
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Recombinant Human CD276 antigen(CD276),partial (Active)
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CSB-MP733578HU
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Mammalian cell
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C-terminal hFc-Myc-tagged
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CD33
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Recombinant Human Myeloid cell surface antigen CD33(CD33),partial (Active)
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CSB-MP004925HU
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Mammalian cell
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C-terminal hFc-Myc-tagged
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CD46
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Recombinant Human Membrane cofactor protein(CD46) (Active)
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CSB-MP004939HU
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Mammalian cell
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C-terminal hFc-tagged
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CLDN18
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Recombinant Human Claudin-18.2(CLDN18.2)-VLPs (Active)
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CSB-MP005498HU(A5)
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Mammalian cell
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C-terminal 10xHis-tagged
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DLL3
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Recombinant Human Delta-like protein 3(DLL3),partial (Active)
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CSB-MP882142HU
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Mammalian cell
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C-terminal 6xHis-tagged
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DLL3
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Recombinant Macaca fascicularis Delta-like protein 3(DLL3),partial (Active)
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CSB-MP3536MOV
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Mammalian cell
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C-terminal 6xHis-tagged
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EGFR
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Recombinant Human Epidermal growth factor receptor(EGFR),partial (Active)
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CSB-MP007479HU
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Mammalian cell
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N-terminal 10xHis-tagged and C-terminal Myc-tagged
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ERBB2
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Recombinant Human Receptor tyrosine-protein kinase erbB-2(ERBB2),partial (Active)
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CSB-MP007763HU
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Mammalian cell
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C-terminal 6xHis-tagged
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ERBB3
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Recombinant Human Receptor tyrosine-protein kinase erbB-3(ERBB3),partial (Active)
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CSB-MP007765HU
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Mammalian cell
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C-terminal hFc-tagged
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MET
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Recombinant Human Hepatocyte growth factor receptor(MET),partial (Active)
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CSB-MP013714HU
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Mammalian cell
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C-terminal hFc-tagged
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MS4A1
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Recombinant Human B-lymphocyte antigen CD20(MS4A1)-VLPs (Active)
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CSB-MP015007HU
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Mammalian cell
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C-terminal 10xHis-tagged
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MSLN
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Recombinant Human Mesothelin(MSLN),partial (Active)
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CSB-MP015044HUc9
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Mammalian cell
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N-terminal hFc-tagged
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NECTIN4
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Recombinant Human Nectin-4(NECTIN4),partial (Active)
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CSB-MP822274HU
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Mammalian cell
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C-terminal 10xHis-tagged
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ROR1
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Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1(ROR1),partial (Active)
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CSB-MP020067HU1d7
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Mammalian cell
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C-terminal 10xHis-tagged
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TACSTD2
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Recombinant Human Tumor-associated calcium signal transducer 2(TACSTD2),partial (Active)
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CSB-MP023072HU1
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Mammalian cell
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C-terminal hFc-tagged
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TNF
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Recombinant Human Tumor necrosis factor(TNF),partial (Active)
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CSB-EP023955HUc7
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E.coli
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C-terminal 6xHis-tagged
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TNFRSF10B
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Recombinant Human Tumor necrosis factor receptor superfamily member 10B(TNFRSF10B),Partial (Active)
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CSB-AP002291HU
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E.coli
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Tag-Free
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TNFRSF17
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Recombinant Human Tumor necrosis factor receptor superfamily member 17(TNFRSF17),partial (Active)
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CSB-MP023974HU1
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Mammalian cell
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C-terminal hFc-tagged
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TNFSF8
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Recombinant Human Tumor necrosis factor ligand superfamily member 8(TNFSF8),partial (Active)
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CSB-MP023996HU1
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Mammalian cell
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N-terminal 6xHis-tagged
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TNFSF8
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Recombinant Human Tumor necrosis factor ligand superfamily member 8(TNFSF8),partial (Active)
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CSB-MP023996HU1c9
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Mammalian cell
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N-terminal hFc-tagged
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更多ADC標的
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